CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING
A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also r...
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| creator | DUFFY, Kevin J Yiqian LIAN ADAMS, Jerry Leroy |
| description | A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Un compuesto de fórmula (I) (ver Fórmula) en donde Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 y R9 son como se define en la presente; y sales y tautómeros farmacéuticamente aceptables de estos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación; la invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos en el tratamiento de enfermedades en las cuales la modulación de STING (estimulador de los genes de interferón) es beneficiosa, por ejemplo inflamación, enfermedades alérgicas y autoinmunes, enfermedades infecciosas, cáncer, síndromes precancerosos y como adyuvantes de vacunas. |
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Un compuesto de fórmula (I) (ver Fórmula) en donde Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 y R9 son como se define en la presente; y sales y tautómeros farmacéuticamente aceptables de estos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación; la invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos en el tratamiento de enfermedades en las cuales la modulación de STING (estimulador de los genes de interferón) es beneficiosa, por ejemplo inflamación, enfermedades alérgicas y autoinmunes, enfermedades infecciosas, cáncer, síndromes precancerosos y como adyuvantes de vacunas.</description><language>eng ; spa</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190403&DB=EPODOC&CC=MX&NR=363780B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190403&DB=EPODOC&CC=MX&NR=363780B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DUFFY, Kevin J</creatorcontrib><creatorcontrib>Yiqian LIAN</creatorcontrib><creatorcontrib>ADAMS, Jerry Leroy</creatorcontrib><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><description>A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Un compuesto de fórmula (I) (ver Fórmula) en donde Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 y R9 son como se define en la presente; y sales y tautómeros farmacéuticamente aceptables de estos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación; la invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos en el tratamiento de enfermedades en las cuales la modulación de STING (estimulador de los genes de interferón) es beneficiosa, por ejemplo inflamación, enfermedades alérgicas y autoinmunes, enfermedades infecciosas, cáncer, síndromes precancerosos y como adyuvantes de vacunas.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDByjnT28XRWCAgN8vRzVXDx9At19nH1D_F0cQ1WcAxW8PV3CfVxDPEPClbwd1MIDvH0c-dhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfG-EcZmxuYWBk7GBBUAAKoyJeE</recordid><startdate>20190403</startdate><enddate>20190403</enddate><creator>DUFFY, Kevin J</creator><creator>Yiqian LIAN</creator><creator>ADAMS, Jerry Leroy</creator><scope>EVB</scope></search><sort><creationdate>20190403</creationdate><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><author>DUFFY, Kevin J ; Yiqian LIAN ; ADAMS, Jerry Leroy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX363780B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>DUFFY, Kevin J</creatorcontrib><creatorcontrib>Yiqian LIAN</creatorcontrib><creatorcontrib>ADAMS, Jerry Leroy</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DUFFY, Kevin J</au><au>Yiqian LIAN</au><au>ADAMS, Jerry Leroy</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><date>2019-04-03</date><risdate>2019</risdate><abstract>A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Un compuesto de fórmula (I) (ver Fórmula) en donde Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 y R9 son como se define en la presente; y sales y tautómeros farmacéuticamente aceptables de estos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y procesos para su preparación; la invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos en el tratamiento de enfermedades en las cuales la modulación de STING (estimulador de los genes de interferón) es beneficiosa, por ejemplo inflamación, enfermedades alérgicas y autoinmunes, enfermedades infecciosas, cáncer, síndromes precancerosos y como adyuvantes de vacunas.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING |
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