IRE-1-ALPHA INHIBITORS
Compounds which directly inhibit IRE-1 alpha activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single...
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| creator | Warren Standfield WADE Zoltan ZUBOVICS Zhipeng WU John Bruce PATTERSON Andras TORO Yun YANG Qingping ZENG |
| description | Compounds which directly inhibit IRE-1 alpha activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
Se describen compuestos que inhiben directamente la actividad de IRE-1a in vitro, profármacos y sales farmacéuticamente aceptable de estos. Los compuestos y profármacos son útiles para tratar enfermedades asociadas con la respuesta a proteínas desplegadas o con la degradación dependiente de IRE-1 regulada (RIDD) y pueden utilizarse como agentes únicos o en terapias de combinación. |
| format | Patent |
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Se describen compuestos que inhiben directamente la actividad de IRE-1a in vitro, profármacos y sales farmacéuticamente aceptable de estos. Los compuestos y profármacos son útiles para tratar enfermedades asociadas con la respuesta a proteínas desplegadas o con la degradación dependiente de IRE-1 regulada (RIDD) y pueden utilizarse como agentes únicos o en terapias de combinación.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190118&DB=EPODOC&CC=MX&NR=362442B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190118&DB=EPODOC&CC=MX&NR=362442B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Warren Standfield WADE</creatorcontrib><creatorcontrib>Zoltan ZUBOVICS</creatorcontrib><creatorcontrib>Zhipeng WU</creatorcontrib><creatorcontrib>John Bruce PATTERSON</creatorcontrib><creatorcontrib>Andras TORO</creatorcontrib><creatorcontrib>Yun YANG</creatorcontrib><creatorcontrib>Qingping ZENG</creatorcontrib><title>IRE-1-ALPHA INHIBITORS</title><description>Compounds which directly inhibit IRE-1 alpha activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
Se describen compuestos que inhiben directamente la actividad de IRE-1a in vitro, profármacos y sales farmacéuticamente aceptable de estos. Los compuestos y profármacos son útiles para tratar enfermedades asociadas con la respuesta a proteínas desplegadas o con la degradación dependiente de IRE-1 regulada (RIDD) y pueden utilizarse como agentes únicos o en terapias de combinación.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDzDHLVNdR19AnwcFTw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDHJuriHOHrqpBfnxqcUFicmpeakl8b4RxmZGJiZGTsYEFQAA8aAd1w</recordid><startdate>20190118</startdate><enddate>20190118</enddate><creator>Warren Standfield WADE</creator><creator>Zoltan ZUBOVICS</creator><creator>Zhipeng WU</creator><creator>John Bruce PATTERSON</creator><creator>Andras TORO</creator><creator>Yun YANG</creator><creator>Qingping ZENG</creator><scope>EVB</scope></search><sort><creationdate>20190118</creationdate><title>IRE-1-ALPHA INHIBITORS</title><author>Warren Standfield WADE ; Zoltan ZUBOVICS ; Zhipeng WU ; John Bruce PATTERSON ; Andras TORO ; Yun YANG ; Qingping ZENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX362442B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Warren Standfield WADE</creatorcontrib><creatorcontrib>Zoltan ZUBOVICS</creatorcontrib><creatorcontrib>Zhipeng WU</creatorcontrib><creatorcontrib>John Bruce PATTERSON</creatorcontrib><creatorcontrib>Andras TORO</creatorcontrib><creatorcontrib>Yun YANG</creatorcontrib><creatorcontrib>Qingping ZENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Warren Standfield WADE</au><au>Zoltan ZUBOVICS</au><au>Zhipeng WU</au><au>John Bruce PATTERSON</au><au>Andras TORO</au><au>Yun YANG</au><au>Qingping ZENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IRE-1-ALPHA INHIBITORS</title><date>2019-01-18</date><risdate>2019</risdate><abstract>Compounds which directly inhibit IRE-1 alpha activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
Se describen compuestos que inhiben directamente la actividad de IRE-1a in vitro, profármacos y sales farmacéuticamente aceptable de estos. Los compuestos y profármacos son útiles para tratar enfermedades asociadas con la respuesta a proteínas desplegadas o con la degradación dependiente de IRE-1 regulada (RIDD) y pueden utilizarse como agentes únicos o en terapias de combinación.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | IRE-1-ALPHA INHIBITORS |
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