SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS
The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi; R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phen...
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| creator | LEBOLD, Terry P PREVILLE, Cathy COATE, Heather R FITZGERALD, Anne E SHIREMAN, Brock T DVORAK, Curt A |
| description | The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi; R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazofyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolvl, pyrrolidinyl, thiophenyi, morpholinyl, or dialkyiamino; R2 is H, alkyl, aikoxy, hydroxyalkylene, or halo; Z is NH, N- alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, qumazolinyi, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substiiuents independently selected from the group consisting of alkyl, aikoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
La presente invención está dirigida a compuestos de la Fórmula I: (ver Fórmula) en donde el anillo A es fenilo, nafihalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tlisazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo; R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazofilo, piridilo, pirimidinilo, pirazinilo, piridazmilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo o dialquilamino; R2 es H, alquilo, alcoxi, hidroxialquileno o halo; Z es NH, N-alquilo u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazmilo, cumazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, sustituidos opcionalmente con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en alquilo, alcoxi o halo; y n es 0 ó 1; también se describen los métodos para hacer los compuestos de la Fórmula I; la invención también se relaciona con composiciones farmacéuticas que comprenden compuestos de la Fórmula I; los métodos de uso de los compuestos de la invención también están dentro del alcance de la invención. |
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La presente invención está dirigida a compuestos de la Fórmula I: (ver Fórmula) en donde el anillo A es fenilo, nafihalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tlisazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo; R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazofilo, piridilo, pirimidinilo, pirazinilo, piridazmilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo o dialquilamino; R2 es H, alquilo, alcoxi, hidroxialquileno o halo; Z es NH, N-alquilo u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazmilo, cumazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, sustituidos opcionalmente con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en alquilo, alcoxi o halo; y n es 0 ó 1; también se describen los métodos para hacer los compuestos de la Fórmula I; la invención también se relaciona con composiciones farmacéuticas que comprenden compuestos de la Fórmula I; los métodos de uso de los compuestos de la invención también están dentro del alcance de la invención.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181115&DB=EPODOC&CC=MX&NR=360791B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20181115&DB=EPODOC&CC=MX&NR=360791B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEBOLD, Terry P</creatorcontrib><creatorcontrib>PREVILLE, Cathy</creatorcontrib><creatorcontrib>COATE, Heather R</creatorcontrib><creatorcontrib>FITZGERALD, Anne E</creatorcontrib><creatorcontrib>SHIREMAN, Brock T</creatorcontrib><creatorcontrib>DVORAK, Curt A</creatorcontrib><title>SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS</title><description>The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi; R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazofyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolvl, pyrrolidinyl, thiophenyi, morpholinyl, or dialkyiamino; R2 is H, alkyl, aikoxy, hydroxyalkylene, or halo; Z is NH, N- alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, qumazolinyi, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substiiuents independently selected from the group consisting of alkyl, aikoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
La presente invención está dirigida a compuestos de la Fórmula I: (ver Fórmula) en donde el anillo A es fenilo, nafihalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tlisazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo; R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazofilo, piridilo, pirimidinilo, pirazinilo, piridazmilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo o dialquilamino; R2 es H, alquilo, alcoxi, hidroxialquileno o halo; Z es NH, N-alquilo u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazmilo, cumazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, sustituidos opcionalmente con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en alquilo, alcoxi o halo; y n es 0 ó 1; también se describen los métodos para hacer los compuestos de la Fórmula I; la invención también se relaciona con composiciones farmacéuticas que comprenden compuestos de la Fórmula I; los métodos de uso de los compuestos de la invención también están dentro del alcance de la invención.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHANDnUKDvEMCQ1xdVEw13WMcnTydI509nENVnD0c1EI8XD1DFIIDXZVcAxW8A9yjfD0UwhydXYNCPEPUvD1dwn1cQSygnkYWNMSc4pTeaE0N4Ocm2uIs4duakF-fGpxQWJyal5qSbxvhLGZgbmloZMxQQUAmacrJQ</recordid><startdate>20181115</startdate><enddate>20181115</enddate><creator>LEBOLD, Terry P</creator><creator>PREVILLE, Cathy</creator><creator>COATE, Heather R</creator><creator>FITZGERALD, Anne E</creator><creator>SHIREMAN, Brock T</creator><creator>DVORAK, Curt A</creator><scope>EVB</scope></search><sort><creationdate>20181115</creationdate><title>SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS</title><author>LEBOLD, Terry P ; PREVILLE, Cathy ; COATE, Heather R ; FITZGERALD, Anne E ; SHIREMAN, Brock T ; DVORAK, Curt A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX360791B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LEBOLD, Terry P</creatorcontrib><creatorcontrib>PREVILLE, Cathy</creatorcontrib><creatorcontrib>COATE, Heather R</creatorcontrib><creatorcontrib>FITZGERALD, Anne E</creatorcontrib><creatorcontrib>SHIREMAN, Brock T</creatorcontrib><creatorcontrib>DVORAK, Curt A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEBOLD, Terry P</au><au>PREVILLE, Cathy</au><au>COATE, Heather R</au><au>FITZGERALD, Anne E</au><au>SHIREMAN, Brock T</au><au>DVORAK, Curt A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS</title><date>2018-11-15</date><risdate>2018</risdate><abstract>The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi; R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazofyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolvl, pyrrolidinyl, thiophenyi, morpholinyl, or dialkyiamino; R2 is H, alkyl, aikoxy, hydroxyalkylene, or halo; Z is NH, N- alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, qumazolinyi, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substiiuents independently selected from the group consisting of alkyl, aikoxy, or halo; and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
La presente invención está dirigida a compuestos de la Fórmula I: (ver Fórmula) en donde el anillo A es fenilo, nafihalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tlisazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo; R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazofilo, piridilo, pirimidinilo, pirazinilo, piridazmilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo o dialquilamino; R2 es H, alquilo, alcoxi, hidroxialquileno o halo; Z es NH, N-alquilo u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazmilo, cumazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, sustituidos opcionalmente con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en alquilo, alcoxi o halo; y n es 0 ó 1; también se describen los métodos para hacer los compuestos de la Fórmula I; la invención también se relaciona con composiciones farmacéuticas que comprenden compuestos de la Fórmula I; los métodos de uso de los compuestos de la invención también están dentro del alcance de la invención.</abstract><oa>free_for_read</oa></addata></record> |
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| title | SUBSTITUTED 7-AZABICYCLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS |
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