HUMAN ANTIBODIES AGAINST HUMAN TISSUE FACTOR

HUMAN ANTIBODIES AGAINST HUMAN TISSUE FACTOR

Isolated human monoclonal antibodies which bind to human TF and related antibody- based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies. La presente invención se refie...

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Bibliographische Detailangaben
Hauptverfasser: TOM VINK, MAROESKA OUDSHOORN, DAVID P.E. SATIJN, SANDRA VERPLOEGEN, PAUL PARREN, VIBEKE MILLER BREINHOLT, ROB N. DE JONG, OLE BAADSGAARD, WILLEM KAREL BLEEKER, EVA EHRNROOTH, RENE M.A. HOET, MISCHA HOUTKAMP, JAN VAN DE WINKEL
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Isolated human monoclonal antibodies which bind to human TF and related antibody- based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies. La presente invención se refiere a un anticuerpo humano el cual une factor tisular (TF), caracterizado porque: compite por unión de TF con un anticuerpo de referencia que comprende una región VH que comprende la SEC ID NO: 9 y una región VL que comprende la secuencia de las SEC ID NO: 65, y no compite por unión de TF con un anticuerpo de referencia que comprende una región VH que comprende la secuencia de la SEC ID NO: 37 y una región VL que comprende la secuencia de la SEC ID NO: 93.