PROCESSES FOR THE PREPARATION OF THE CRYSTALLINE FORM A OF SELPERCATINIB. A RET INHIBITOR
Provided herein are methods of preparing crystalline, selpercatinib Form A, which contains little to none of the thermodynamically more stable, crystalline selpercatinib Form B. Selpercatinib is useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, incl...
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| creator | MERRITT Jeremy Miles SELBO Jon Gordon BHARDWAJ Rajni Miglani |
| description | Provided herein are methods of preparing crystalline, selpercatinib Form A, which contains little to none of the thermodynamically more stable, crystalline selpercatinib Form B. Selpercatinib is useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
En la presente descripción se proporcionan métodos para preparar la Forma A de selpercatinib cristalino, que contiene poco o nada de la Forma B de selpercatinib cristalino termodinámicamente más estable. El selpercatinib es útil en el tratamiento y la prevención de enfermedades que pueden tratarse con un inhibidor de la cinasa RET, incluidas enfermedades y trastornos asociados con RET. |
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En la presente descripción se proporcionan métodos para preparar la Forma A de selpercatinib cristalino, que contiene poco o nada de la Forma B de selpercatinib cristalino termodinámicamente más estable. El selpercatinib es útil en el tratamiento y la prevención de enfermedades que pueden tratarse con un inhibidor de la cinasa RET, incluidas enfermedades y trastornos asociados con RET.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240619&DB=EPODOC&CC=MX&NR=2024007017A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240619&DB=EPODOC&CC=MX&NR=2024007017A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MERRITT Jeremy Miles</creatorcontrib><creatorcontrib>SELBO Jon Gordon</creatorcontrib><creatorcontrib>BHARDWAJ Rajni Miglani</creatorcontrib><title>PROCESSES FOR THE PREPARATION OF THE CRYSTALLINE FORM A OF SELPERCATINIB. A RET INHIBITOR</title><description>Provided herein are methods of preparing crystalline, selpercatinib Form A, which contains little to none of the thermodynamically more stable, crystalline selpercatinib Form B. Selpercatinib is useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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En la presente descripción se proporcionan métodos para preparar la Forma A de selpercatinib cristalino, que contiene poco o nada de la Forma B de selpercatinib cristalino termodinámicamente más estable. El selpercatinib es útil en el tratamiento y la prevención de enfermedades que pueden tratarse con un inhibidor de la cinasa RET, incluidas enfermedades y trastornos asociados con RET.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESSES FOR THE PREPARATION OF THE CRYSTALLINE FORM A OF SELPERCATINIB. A RET INHIBITOR |
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