DR5-TARGETING MULTABODIES FOR THE TREATMENT OF CANCER

Self-assembled polypeptide complexes comprising 1) fusion polypeptides comprising Fc polypeptides linked to nanocage monomers or subunits thereof and 2) fusion polypeptides comprising an antigen-binding antibody fragment capable of binding to DR5. Complejos polipeptídicos autoensamblados que compren...

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Hauptverfasser:	JULIEN Jean-philippe, RUJAS DIEZ Edurne, HE Xinwen, HULME Joanne, BEILSCHMIDT Melissa, BAYLISS Peter Edward
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Self-assembled polypeptide complexes comprising 1) fusion polypeptides comprising Fc polypeptides linked to nanocage monomers or subunits thereof and 2) fusion polypeptides comprising an antigen-binding antibody fragment capable of binding to DR5. Complejos polipeptídicos autoensamblados que comprenden 1) polipéptidos de fusión que comprenden polipéptidos Fc unidos a monómeros de nanojaula o subunidades de estos y 2) polipéptidos de fusión que comprenden un fragmento de anticuerpo de unión al antígeno capaz de unirse a DR5.