FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF
The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are usef...
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| creator | HAN Cheolkyu KIM Namhee SHIN Youngdo KIM Sunjoo YOON Cheolhwan LEE Jinwoo KANG Byungnam SEO Jeongbeob KANG Hongjun YANG Inho LEE Jungwoo |
| description | The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are useful in the treatment of chronic fibrosis, vascular disorder, obesity, diabetes, autoimmune diseases and cancer.
La invención proporciona nuevos compuestos heterocíclicos sustituidos representados por la fórmula I, o una sal, solvato, polimorfo, éster, tautómero o profármaco farmacéuticamente aceptable de los mismos, y una composición que comprende estos compuestos. Los compuestos proporcionados pueden usarse como inhibidores de ALK5 y son útiles en el tratamiento de la fibrosis crónica, trastornos vasculares, obesidad, diabetes, enfermedades autoinmunes y cáncer. |
| format | Patent |
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La invención proporciona nuevos compuestos heterocíclicos sustituidos representados por la fórmula I, o una sal, solvato, polimorfo, éster, tautómero o profármaco farmacéuticamente aceptable de los mismos, y una composición que comprende estos compuestos. Los compuestos proporcionados pueden usarse como inhibidores de ALK5 y son útiles en el tratamiento de la fibrosis crónica, trastornos vasculares, obesidad, diabetes, enfermedades autoinmunes y cáncer.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240227&DB=EPODOC&CC=MX&NR=2024001751A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240227&DB=EPODOC&CC=MX&NR=2024001751A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAN Cheolkyu</creatorcontrib><creatorcontrib>KIM Namhee</creatorcontrib><creatorcontrib>SHIN Youngdo</creatorcontrib><creatorcontrib>KIM Sunjoo</creatorcontrib><creatorcontrib>YOON Cheolhwan</creatorcontrib><creatorcontrib>LEE Jinwoo</creatorcontrib><creatorcontrib>KANG Byungnam</creatorcontrib><creatorcontrib>SEO Jeongbeob</creatorcontrib><creatorcontrib>KANG Hongjun</creatorcontrib><creatorcontrib>YANG Inho</creatorcontrib><creatorcontrib>LEE Jungwoo</creatorcontrib><title>FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF</title><description>The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are useful in the treatment of chronic fibrosis, vascular disorder, obesity, diabetes, autoimmune diseases and cancer.
La invención proporciona nuevos compuestos heterocíclicos sustituidos representados por la fórmula I, o una sal, solvato, polimorfo, éster, tautómero o profármaco farmacéuticamente aceptable de los mismos, y una composición que comprende estos compuestos. Los compuestos proporcionados pueden usarse como inhibidores de ALK5 y son útiles en el tratamiento de la fibrosis crónica, trastornos vasculares, obesidad, diabetes, enfermedades autoinmunes y cáncer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB3Cw12dVEI8vRzV_BwDXEN8ncMivRRcPb3DfAP9XMJVnD0c1EAKlEI8XANcvV342FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8b4RRgZGJgYGhuamho7GRCkCAFVmJnc</recordid><startdate>20240227</startdate><enddate>20240227</enddate><creator>HAN Cheolkyu</creator><creator>KIM Namhee</creator><creator>SHIN Youngdo</creator><creator>KIM Sunjoo</creator><creator>YOON Cheolhwan</creator><creator>LEE Jinwoo</creator><creator>KANG Byungnam</creator><creator>SEO Jeongbeob</creator><creator>KANG Hongjun</creator><creator>YANG Inho</creator><creator>LEE Jungwoo</creator><scope>EVB</scope></search><sort><creationdate>20240227</creationdate><title>FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF</title><author>HAN Cheolkyu ; KIM Namhee ; SHIN Youngdo ; KIM Sunjoo ; YOON Cheolhwan ; LEE Jinwoo ; KANG Byungnam ; SEO Jeongbeob ; KANG Hongjun ; YANG Inho ; LEE Jungwoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2024001751A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HAN Cheolkyu</creatorcontrib><creatorcontrib>KIM Namhee</creatorcontrib><creatorcontrib>SHIN Youngdo</creatorcontrib><creatorcontrib>KIM Sunjoo</creatorcontrib><creatorcontrib>YOON Cheolhwan</creatorcontrib><creatorcontrib>LEE Jinwoo</creatorcontrib><creatorcontrib>KANG Byungnam</creatorcontrib><creatorcontrib>SEO Jeongbeob</creatorcontrib><creatorcontrib>KANG Hongjun</creatorcontrib><creatorcontrib>YANG Inho</creatorcontrib><creatorcontrib>LEE Jungwoo</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAN Cheolkyu</au><au>KIM Namhee</au><au>SHIN Youngdo</au><au>KIM Sunjoo</au><au>YOON Cheolhwan</au><au>LEE Jinwoo</au><au>KANG Byungnam</au><au>SEO Jeongbeob</au><au>KANG Hongjun</au><au>YANG Inho</au><au>LEE Jungwoo</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF</title><date>2024-02-27</date><risdate>2024</risdate><abstract>The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of ALK5 and are useful in the treatment of chronic fibrosis, vascular disorder, obesity, diabetes, autoimmune diseases and cancer.
La invención proporciona nuevos compuestos heterocíclicos sustituidos representados por la fórmula I, o una sal, solvato, polimorfo, éster, tautómero o profármaco farmacéuticamente aceptable de los mismos, y una composición que comprende estos compuestos. Los compuestos proporcionados pueden usarse como inhibidores de ALK5 y son útiles en el tratamiento de la fibrosis crónica, trastornos vasculares, obesidad, diabetes, enfermedades autoinmunes y cáncer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF |
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