ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF
The present invention relates to: a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2); an active metabolite of the ADC; a method for producing the ADC; a use of the ADC for treating and/or preventing diseases; and a use of the ADC for producing medicaments for treating an...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; spa |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | JANG TAE Ik SONG HO Young PARK CHANG Sik JHENG MING Jin CHUNG CHUL Woong |
| description | The present invention relates to: a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2); an active metabolite of the ADC; a method for producing the ADC; a use of the ADC for treating and/or preventing diseases; and a use of the ADC for producing medicaments for treating and/or preventing diseases, more specifically, hyperproliferative and/or angiogenic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding to CLDN18.2 or an antigen-binding fragment thereof, and to a pharmaceutical composition comprising same.
La presente invención se relaciona con: un conjugado anticuerpo-fármaco novedoso (ADC) que actúa sobre la isoforma 2 de la claudina 18 (CLDN18.2); un metabolito activo del ADC; un método para producir el ADC; un uso del ADC para tratar y/o prevenir enfermedades; y un uso del ADC para producir medicamentos para tratar y/o prevenir enfermedades, más específicamente, enfermedades hiperproliferativas y/o angiogénicas, por ejemplo, cáncer. Más particularmente, la presente invención se relaciona con un conjugado anticuerpo-fármaco que comprende un anticuerpo que se une a la CLDN18.2 o un fragmento de unión a antígeno del mismo, y con una composición farmacéutica que comprende el mismo. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_MX2023011507A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MX2023011507A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_MX2023011507A3</originalsourceid><addsrcrecordid>eNrjZAhy9AvxdPJ3idR1CQp1V3D29_MKdXcMcVXw9HP2CXXx9HNXgKlQcHR39PQLDlHwCPV19FNw9nHxM7TQM9IBKnBRCA12VQjxcA1y9XfjYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxvhFGBkbGBoaGpgbmjsZEKQIA_EQvgA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF</title><source>esp@cenet</source><creator>JANG TAE Ik ; SONG HO Young ; PARK CHANG Sik ; JHENG MING Jin ; CHUNG CHUL Woong</creator><creatorcontrib>JANG TAE Ik ; SONG HO Young ; PARK CHANG Sik ; JHENG MING Jin ; CHUNG CHUL Woong</creatorcontrib><description>The present invention relates to: a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2); an active metabolite of the ADC; a method for producing the ADC; a use of the ADC for treating and/or preventing diseases; and a use of the ADC for producing medicaments for treating and/or preventing diseases, more specifically, hyperproliferative and/or angiogenic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding to CLDN18.2 or an antigen-binding fragment thereof, and to a pharmaceutical composition comprising same.
La presente invención se relaciona con: un conjugado anticuerpo-fármaco novedoso (ADC) que actúa sobre la isoforma 2 de la claudina 18 (CLDN18.2); un metabolito activo del ADC; un método para producir el ADC; un uso del ADC para tratar y/o prevenir enfermedades; y un uso del ADC para producir medicamentos para tratar y/o prevenir enfermedades, más específicamente, enfermedades hiperproliferativas y/o angiogénicas, por ejemplo, cáncer. Más particularmente, la presente invención se relaciona con un conjugado anticuerpo-fármaco que comprende un anticuerpo que se une a la CLDN18.2 o un fragmento de unión a antígeno del mismo, y con una composición farmacéutica que comprende el mismo.</description><language>eng ; spa</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231004&DB=EPODOC&CC=MX&NR=2023011507A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231004&DB=EPODOC&CC=MX&NR=2023011507A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JANG TAE Ik</creatorcontrib><creatorcontrib>SONG HO Young</creatorcontrib><creatorcontrib>PARK CHANG Sik</creatorcontrib><creatorcontrib>JHENG MING Jin</creatorcontrib><creatorcontrib>CHUNG CHUL Woong</creatorcontrib><title>ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF</title><description>The present invention relates to: a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2); an active metabolite of the ADC; a method for producing the ADC; a use of the ADC for treating and/or preventing diseases; and a use of the ADC for producing medicaments for treating and/or preventing diseases, more specifically, hyperproliferative and/or angiogenic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding to CLDN18.2 or an antigen-binding fragment thereof, and to a pharmaceutical composition comprising same.
La presente invención se relaciona con: un conjugado anticuerpo-fármaco novedoso (ADC) que actúa sobre la isoforma 2 de la claudina 18 (CLDN18.2); un metabolito activo del ADC; un método para producir el ADC; un uso del ADC para tratar y/o prevenir enfermedades; y un uso del ADC para producir medicamentos para tratar y/o prevenir enfermedades, más específicamente, enfermedades hiperproliferativas y/o angiogénicas, por ejemplo, cáncer. Más particularmente, la presente invención se relaciona con un conjugado anticuerpo-fármaco que comprende un anticuerpo que se une a la CLDN18.2 o un fragmento de unión a antígeno del mismo, y con una composición farmacéutica que comprende el mismo.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAhy9AvxdPJ3idR1CQp1V3D29_MKdXcMcVXw9HP2CXXx9HNXgKlQcHR39PQLDlHwCPV19FNw9nHxM7TQM9IBKnBRCA12VQjxcA1y9XfjYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxvhFGBkbGBoaGpgbmjsZEKQIA_EQvgA</recordid><startdate>20231004</startdate><enddate>20231004</enddate><creator>JANG TAE Ik</creator><creator>SONG HO Young</creator><creator>PARK CHANG Sik</creator><creator>JHENG MING Jin</creator><creator>CHUNG CHUL Woong</creator><scope>EVB</scope></search><sort><creationdate>20231004</creationdate><title>ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF</title><author>JANG TAE Ik ; SONG HO Young ; PARK CHANG Sik ; JHENG MING Jin ; CHUNG CHUL Woong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2023011507A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JANG TAE Ik</creatorcontrib><creatorcontrib>SONG HO Young</creatorcontrib><creatorcontrib>PARK CHANG Sik</creatorcontrib><creatorcontrib>JHENG MING Jin</creatorcontrib><creatorcontrib>CHUNG CHUL Woong</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JANG TAE Ik</au><au>SONG HO Young</au><au>PARK CHANG Sik</au><au>JHENG MING Jin</au><au>CHUNG CHUL Woong</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF</title><date>2023-10-04</date><risdate>2023</risdate><abstract>The present invention relates to: a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2); an active metabolite of the ADC; a method for producing the ADC; a use of the ADC for treating and/or preventing diseases; and a use of the ADC for producing medicaments for treating and/or preventing diseases, more specifically, hyperproliferative and/or angiogenic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding to CLDN18.2 or an antigen-binding fragment thereof, and to a pharmaceutical composition comprising same.
La presente invención se relaciona con: un conjugado anticuerpo-fármaco novedoso (ADC) que actúa sobre la isoforma 2 de la claudina 18 (CLDN18.2); un metabolito activo del ADC; un método para producir el ADC; un uso del ADC para tratar y/o prevenir enfermedades; y un uso del ADC para producir medicamentos para tratar y/o prevenir enfermedades, más específicamente, enfermedades hiperproliferativas y/o angiogénicas, por ejemplo, cáncer. Más particularmente, la presente invención se relaciona con un conjugado anticuerpo-fármaco que comprende un anticuerpo que se une a la CLDN18.2 o un fragmento de unión a antígeno del mismo, y con una composición farmacéutica que comprende el mismo.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; spa |
| recordid | cdi_epo_espacenet_MX2023011507A |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTIBODY-DRUG CONJUGATE INCLUDING ANTIBODY AGAINST HUMAN CLDN18.2, AND USE THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A07%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JANG%20TAE%20Ik&rft.date=2023-10-04&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EMX2023011507A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |