DIHYDROERGOTAMINE DRY POWER FORMULATIONS AND METHODS OF USE

The present disclosure relates to dry powder formulations comprising respirable dry particles that comprise 1) dihydroergotamine (DHE) or a salt, hydrate, or polymorph thereof, 2) a monovalent metal cation salt, and 3) one or more excipients; and also relates to methods of using the dry powder for t...

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Hauptverfasser: HANSON Dayna F, GONZALEZ NELSON Aaron C, BERGSON Hillary T, CURRAN Aidan K, STOLZ Eric C, PERRY Jason M
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Sprache:eng ; spa
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creator HANSON Dayna F
GONZALEZ NELSON Aaron C
BERGSON Hillary T
CURRAN Aidan K
STOLZ Eric C
PERRY Jason M
description The present disclosure relates to dry powder formulations comprising respirable dry particles that comprise 1) dihydroergotamine (DHE) or a salt, hydrate, or polymorph thereof, 2) a monovalent metal cation salt, and 3) one or more excipients; and also relates to methods of using the dry powder for the treatment of a migraine, headache, or a symptom thereof, methods of making the dry powder, and receptacles and devices containing the dry powder. La presente divulgación se refiere a formulaciones de polvo seco que comprenden partículas secas respirables que comprenden 1) dihidroergotamina (DHE) o una sal, hidrato o polimorfo de esta, 2) una sal de catión metálico monovalente y 3) uno o más excipientes; y también se refiere a métodos para usar el polvo seco para el tratamiento de una migraña, cefalea o un síntoma de esta, métodos para preparar el polvo seco y receptáculos y dispositivos que contienen el polvo seco.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DIHYDROERGOTAMINE DRY POWER FORMULATIONS AND METHODS OF USE
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