HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS
The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the inve...
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| creator | CUZZOLIN Alberto ACCETTA Alessandro ZIHER Dinko ELENKOV Ivaylo MESIC Milan RIZZI Andrea ZADRAVEC Rahela RANCATI Fabio |
| description | The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.
La presente invención se refiere a compuestos de la fórmula general (I) que inhiben la familia JAK de tirosina proteína cinasas no receptoras (JAK1, JAK2, JAK3 y TYK2), métodos para preparar estos compuestos, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de enfermedades o condiciones asociadas con una desregulación de las cinasas no receptoras de la familia JAK; en particular para el tratamiento de varias enfermedades inflamatorias que incluyen asma, COPD y otras enfermedades respiratorias. |
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La presente invención se refiere a compuestos de la fórmula general (I) que inhiben la familia JAK de tirosina proteína cinasas no receptoras (JAK1, JAK2, JAK3 y TYK2), métodos para preparar estos compuestos, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de enfermedades o condiciones asociadas con una desregulación de las cinasas no receptoras de la familia JAK; en particular para el tratamiento de varias enfermedades inflamatorias que incluyen asma, COPD y otras enfermedades respiratorias.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230907&DB=EPODOC&CC=MX&NR=2023010083A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230907&DB=EPODOC&CC=MX&NR=2023010083A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CUZZOLIN Alberto</creatorcontrib><creatorcontrib>ACCETTA Alessandro</creatorcontrib><creatorcontrib>ZIHER Dinko</creatorcontrib><creatorcontrib>ELENKOV Ivaylo</creatorcontrib><creatorcontrib>MESIC Milan</creatorcontrib><creatorcontrib>RIZZI Andrea</creatorcontrib><creatorcontrib>ZADRAVEC Rahela</creatorcontrib><creatorcontrib>RANCATI Fabio</creatorcontrib><title>HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS</title><description>The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS |
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