COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZO LO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS
In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning...
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| creator | GILBERTSON Scott R DILSHA Kasuni PAGBA Cynthia V ABEBE Alemayehu Gorfe |
| description | In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
En un aspecto, la descripción se refiere a compuestos útiles como inhibidores de proteínas KRAS mutantes, métodos para elaborarlos, composiciones farmacéuticas que comprenden los mismos y métodos para tratar cánceres asociados con formas mutadas de KRAS usando los mismos. Se propone que este resumen sea una herramienta de exploración para fines de búsqueda en la técnica particular y no se propone que sea limitante de la presente descripción. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZO LO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS |
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