POLYMORPHIC FORM OF MEISOINDIGO AND MODIFIED FORMULATION OF MEISOINDIGO

The present invention relates to a novel crystal form, manufacturing procedures, pharmaceutical compositions, formulations and medicaments comprising a N-methylisoindigo crystalline, methods of preparation, and the use of the N-methylisoindigo crystalline to prepare a medicament to prevent cancer, or treat cancer or an inflammatory-related disease associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. La presente invención se relaciona a una forma de cristal novedosa, procedimientos de manufactura, composiciones farmacéuticas, formulaciones y medicamentos que comprenden un N-metilisoindigo cristalino, métodos de preparación y el uso de N-metilisoindigo cristalino para preparar un medicamento para prevenir cáncer o tratar cáncer o una enfermedad inflamatoria relacionada asociada con la expresion de citocina proinflamatoria y/o expresion reducida de citocinas anti inflamatorias.