VARIANTS OF CD38 ANTIBODY AND USES THEREOF

Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index. Va...

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Bibliographische Detailangaben
Hauptverfasser:	BEURSKENS Frank, SCHUURMAN Janine, SATIJN David, E C G DE GOEIJ Bart, ANDRINGA Grietje, AHMADI Tahamtan
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index. Variantes de anticuerpos que comprenden una o más mutaciones en la región Fc, en particular anticuerpos anti-CD38 que comprenden una mutación en uno o más restos de aminoácido correspondientes a E430, E345 y S440 en una cadena pesada de IgG1 humana, en donde los restos de aminoácidos están numerados de acuerdo con el índice de la UE.