MULTIVARIATE SPECTRAL ANALYSIS AND MONITORING OF BIOMANUFACTURING
The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing...
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| creator | WASALATHANTHRI Dhanuka Pulasthi POLLOCK Julie Susanne BARRETT Shawn L TEWARI Jagdish C KANG Xuezhen HINCAPIE Marina |
| description | The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum (806) using a second chemometrics model to determine a value of a second quality attribute (812) associated with the solution, and adjusting at least one parameter (810) of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.
La divulgación presenta métodos que incluyen obtener un espectro vibracional de una disolución en un sistema de preparación biológica, analizar el espectro vibracional usando un primer modelo quimiométrico para determinar un valor de un primer atributo de calidad asociado con la disolución, analizar el espectro vibracional usando un segundo modelo quimiométrico para determinar un valor de un segundo atributo de calidad asociado con la disolución, y ajustar al menos un parámetro de una unidad de purificación del sistema de preparación biológica con base en al menos uno de los valores del primer y segundo atributo de calidad.. |
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La divulgación presenta métodos que incluyen obtener un espectro vibracional de una disolución en un sistema de preparación biológica, analizar el espectro vibracional usando un primer modelo quimiométrico para determinar un valor de un primer atributo de calidad asociado con la disolución, analizar el espectro vibracional usando un segundo modelo quimiométrico para determinar un valor de un segundo atributo de calidad asociado con la disolución, y ajustar al menos un parámetro de una unidad de purificación del sistema de preparación biológica con base en al menos uno de los valores del primer y segundo atributo de calidad..</description><language>eng ; spa</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PHYSICS ; SEPARATION ; TESTING ; TRANSPORTING</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201211&DB=EPODOC&CC=MX&NR=2020009133A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201211&DB=EPODOC&CC=MX&NR=2020009133A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WASALATHANTHRI Dhanuka Pulasthi</creatorcontrib><creatorcontrib>POLLOCK Julie Susanne</creatorcontrib><creatorcontrib>BARRETT Shawn L</creatorcontrib><creatorcontrib>TEWARI Jagdish C</creatorcontrib><creatorcontrib>KANG Xuezhen</creatorcontrib><creatorcontrib>HINCAPIE Marina</creatorcontrib><title>MULTIVARIATE SPECTRAL ANALYSIS AND MONITORING OF BIOMANUFACTURING</title><description>The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum (806) using a second chemometrics model to determine a value of a second quality attribute (812) associated with the solution, and adjusting at least one parameter (810) of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.
La divulgación presenta métodos que incluyen obtener un espectro vibracional de una disolución en un sistema de preparación biológica, analizar el espectro vibracional usando un primer modelo quimiométrico para determinar un valor de un primer atributo de calidad asociado con la disolución, analizar el espectro vibracional usando un segundo modelo quimiométrico para determinar un valor de un segundo atributo de calidad asociado con la disolución, y ajustar al menos un parámetro de una unidad de purificación del sistema de preparación biológica con base en al menos uno de los valores del primer y segundo atributo de calidad..</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PHYSICS</subject><subject>SEPARATION</subject><subject>TESTING</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD0DfUJ8QxzDPJ0DHFVCA5wdQ4JcvRRcPRz9IkM9gwGMlwUfP39PEP8gzz93BX83RScPP19Hf1C3RydQ0JBYjwMrGmJOcWpvFCam0HJzTXE2UM3tSA_PrW4IDE5NS-1JN43wsjAyMDAwNLQ2NjRmChFAGPzK88</recordid><startdate>20201211</startdate><enddate>20201211</enddate><creator>WASALATHANTHRI Dhanuka Pulasthi</creator><creator>POLLOCK Julie Susanne</creator><creator>BARRETT Shawn L</creator><creator>TEWARI Jagdish C</creator><creator>KANG Xuezhen</creator><creator>HINCAPIE Marina</creator><scope>EVB</scope></search><sort><creationdate>20201211</creationdate><title>MULTIVARIATE SPECTRAL ANALYSIS AND MONITORING OF BIOMANUFACTURING</title><author>WASALATHANTHRI Dhanuka Pulasthi ; POLLOCK Julie Susanne ; BARRETT Shawn L ; TEWARI Jagdish C ; KANG Xuezhen ; HINCAPIE Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2020009133A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2020</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PHYSICS</topic><topic>SEPARATION</topic><topic>TESTING</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>WASALATHANTHRI Dhanuka Pulasthi</creatorcontrib><creatorcontrib>POLLOCK Julie Susanne</creatorcontrib><creatorcontrib>BARRETT Shawn L</creatorcontrib><creatorcontrib>TEWARI Jagdish C</creatorcontrib><creatorcontrib>KANG Xuezhen</creatorcontrib><creatorcontrib>HINCAPIE Marina</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WASALATHANTHRI Dhanuka Pulasthi</au><au>POLLOCK Julie Susanne</au><au>BARRETT Shawn L</au><au>TEWARI Jagdish C</au><au>KANG Xuezhen</au><au>HINCAPIE Marina</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MULTIVARIATE SPECTRAL ANALYSIS AND MONITORING OF BIOMANUFACTURING</title><date>2020-12-11</date><risdate>2020</risdate><abstract>The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum (806) using a second chemometrics model to determine a value of a second quality attribute (812) associated with the solution, and adjusting at least one parameter (810) of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.
La divulgación presenta métodos que incluyen obtener un espectro vibracional de una disolución en un sistema de preparación biológica, analizar el espectro vibracional usando un primer modelo quimiométrico para determinar un valor de un primer atributo de calidad asociado con la disolución, analizar el espectro vibracional usando un segundo modelo quimiométrico para determinar un valor de un segundo atributo de calidad asociado con la disolución, y ajustar al menos un parámetro de una unidad de purificación del sistema de preparación biológica con base en al menos uno de los valores del primer y segundo atributo de calidad..</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; spa |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS SEPARATION TESTING TRANSPORTING |
| title | MULTIVARIATE SPECTRAL ANALYSIS AND MONITORING OF BIOMANUFACTURING |
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