MUCO-ADHESIVE, CONTROLLED RELEASE FORMULATIONS OF LEVODOPA AND/OR ESTERS OF LEVODOPA AND USES THEREOF

The invention provides a controlled release oral solid formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levodopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of...

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Hauptverfasser: Amy DING, Suneel GUPTA, Liang, C. DONG, Ann HSU
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Sprache:eng ; spa
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creator Amy DING
Suneel GUPTA
Liang, C. DONG
Ann HSU
description The invention provides a controlled release oral solid formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levodopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric coated polymer; and (b) a decarboxylase inhibitor component. La invención proporciona una formulación oral sólida de liberación controlada que comprende (a) un componente de liberación controlada que comprende un núcleo que comprende levodopa y/o un éster de levodopa o sus sales, en donde el núcleo está recubierto con una capa de un polímero muco-adhesivo y recubierto externamente con una capa de un polímero de recubrimiento entérico; y (b) un componente inhibidor de descarboxilasa.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title MUCO-ADHESIVE, CONTROLLED RELEASE FORMULATIONS OF LEVODOPA AND/OR ESTERS OF LEVODOPA AND USES THEREOF
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