PROCESSES FOR PREPARING AG-10, ITS INTERMEDIATES, AND SALTS THEREOF
Provided herein are improved processes for the preparation of a compound of Formula IX (AG- 10). Also provided herein are pharmaceutically acceptable salts of Formula (I) and Formula (lb) as well as crystalline types of Formula IX (AG- 10). The processes described herein provide improved yields and...
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| creator | Yogesh, Kumar, GUPTA Rakesh, Kumar, KUMAWAT Mamoun, ALHAMADSHEH Pooran, CHAND Robert, ZAMBONI |
| description | Provided herein are improved processes for the preparation of a compound of Formula IX (AG- 10). Also provided herein are pharmaceutically acceptable salts of Formula (I) and Formula (lb) as well as crystalline types of Formula IX (AG- 10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
Se proporcionan en la presente procesos mejorados para la preparación de un compuesto de la Fórmula IX (AG-10). También se proporcionan en la presente sales farmacéuticamente aceptables de la Fórmula I y Fórmula Ib (ver fórmula) así como tipos cristalinos de la Fórmula IX (AG-10). Los procesos descritos en la presente proporcionan rendimientos y eficiencia mejorados, mientras que las sales farmacéuticamente aceptables y las formas cristalinas proporcionan propiedades farmacocinéticas inesperadas. Otras características y aspectos de la presente descripción serán evidentes para una persona experta en la técnica al leer el resto de la especificación. |
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Se proporcionan en la presente procesos mejorados para la preparación de un compuesto de la Fórmula IX (AG-10). También se proporcionan en la presente sales farmacéuticamente aceptables de la Fórmula I y Fórmula Ib (ver fórmula) así como tipos cristalinos de la Fórmula IX (AG-10). Los procesos descritos en la presente proporcionan rendimientos y eficiencia mejorados, mientras que las sales farmacéuticamente aceptables y las formas cristalinas proporcionan propiedades farmacocinéticas inesperadas. Otras características y aspectos de la presente descripción serán evidentes para una persona experta en la técnica al leer el resto de la especificación.</description><language>eng ; spa</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191111&DB=EPODOC&CC=MX&NR=2019009764A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191111&DB=EPODOC&CC=MX&NR=2019009764A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yogesh, Kumar, GUPTA</creatorcontrib><creatorcontrib>Rakesh, Kumar, KUMAWAT</creatorcontrib><creatorcontrib>Mamoun, ALHAMADSHEH</creatorcontrib><creatorcontrib>Pooran, CHAND</creatorcontrib><creatorcontrib>Robert, ZAMBONI</creatorcontrib><title>PROCESSES FOR PREPARING AG-10, ITS INTERMEDIATES, AND SALTS THEREOF</title><description>Provided herein are improved processes for the preparation of a compound of Formula IX (AG- 10). Also provided herein are pharmaceutically acceptable salts of Formula (I) and Formula (lb) as well as crystalline types of Formula IX (AG- 10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
Se proporcionan en la presente procesos mejorados para la preparación de un compuesto de la Fórmula IX (AG-10). También se proporcionan en la presente sales farmacéuticamente aceptables de la Fórmula I y Fórmula Ib (ver fórmula) así como tipos cristalinos de la Fórmula IX (AG-10). Los procesos descritos en la presente proporcionan rendimientos y eficiencia mejorados, mientras que las sales farmacéuticamente aceptables y las formas cristalinas proporcionan propiedades farmacocinéticas inesperadas. Otras características y aspectos de la presente descripción serán evidentes para una persona experta en la técnica al leer el resto de la especificación.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAOCPJ3dg0Odg1WcPMPUggIcg1wDPL0c1dwdNc1NNBR8AwJVvD0C3EN8nV18XQMcQ3WUXD0c1EIdvQBSoR4uAa5-rvxMLCmJeYUp_JCaW4GJTfXEGcP3dSC_PjU4oLE5NS81JJ43wgjA0NLAwNLczMTR2OiFAEAT_crmQ</recordid><startdate>20191111</startdate><enddate>20191111</enddate><creator>Yogesh, Kumar, GUPTA</creator><creator>Rakesh, Kumar, KUMAWAT</creator><creator>Mamoun, ALHAMADSHEH</creator><creator>Pooran, CHAND</creator><creator>Robert, ZAMBONI</creator><scope>EVB</scope></search><sort><creationdate>20191111</creationdate><title>PROCESSES FOR PREPARING AG-10, ITS INTERMEDIATES, AND SALTS THEREOF</title><author>Yogesh, Kumar, GUPTA ; Rakesh, Kumar, KUMAWAT ; Mamoun, ALHAMADSHEH ; Pooran, CHAND ; Robert, ZAMBONI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2019009764A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Yogesh, Kumar, GUPTA</creatorcontrib><creatorcontrib>Rakesh, Kumar, KUMAWAT</creatorcontrib><creatorcontrib>Mamoun, ALHAMADSHEH</creatorcontrib><creatorcontrib>Pooran, CHAND</creatorcontrib><creatorcontrib>Robert, ZAMBONI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yogesh, Kumar, GUPTA</au><au>Rakesh, Kumar, KUMAWAT</au><au>Mamoun, ALHAMADSHEH</au><au>Pooran, CHAND</au><au>Robert, ZAMBONI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR PREPARING AG-10, ITS INTERMEDIATES, AND SALTS THEREOF</title><date>2019-11-11</date><risdate>2019</risdate><abstract>Provided herein are improved processes for the preparation of a compound of Formula IX (AG- 10). Also provided herein are pharmaceutically acceptable salts of Formula (I) and Formula (lb) as well as crystalline types of Formula IX (AG- 10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
Se proporcionan en la presente procesos mejorados para la preparación de un compuesto de la Fórmula IX (AG-10). También se proporcionan en la presente sales farmacéuticamente aceptables de la Fórmula I y Fórmula Ib (ver fórmula) así como tipos cristalinos de la Fórmula IX (AG-10). Los procesos descritos en la presente proporcionan rendimientos y eficiencia mejorados, mientras que las sales farmacéuticamente aceptables y las formas cristalinas proporcionan propiedades farmacocinéticas inesperadas. Otras características y aspectos de la presente descripción serán evidentes para una persona experta en la técnica al leer el resto de la especificación.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESSES FOR PREPARING AG-10, ITS INTERMEDIATES, AND SALTS THEREOF |
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