A METHOD OF PRODUCING LACTIC ACID
A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate co...
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creator | Magda HOGAN Eamon HOGAN Parikshit Rameshwar SAWDEKAR Bill MORRISSEY Ramesh Babu PADAMATI Colm O''BRIEN |
description | A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate comprising calcium and phosphate, and separating the precipitate from the whey by-product to provide a clarified whey by-product. The clarified whey by-product is fermentated by a bacterium capable of bioconversion of lactose to lactic acid to provide a fermentation broth containing a lactic acid salt. In the downstream steps, the fermentation broth is acidified to release lactic acid from the lactic acid salt, precipitate from the broth produced by acidification is removed, and the acidified fermentation broth is treated to recover pure lactic acid by removal of residual salts, and water, and optionally protein. The process of the invention produces lactic acid having a purity of 80-98% and an isomeric purity of >98% L-lactic acid using a process that employs upstream removal of divalent salts by chemical precipitation, bacterial fermentation of the demineralised substrate, and minimum downstream processing of the fermentation broth. The methods of the invention may also be employed with milk permeates.
Se describe un proceso para producir ácido láctico puro a partir de un subproducto del suero de leche rico en lactosa y minerales, por ejemplo, permeado del suero de leche deslactosado o permeado del suero de leche concentrado. El método comprende etapas anteriores de neutralización del subproducto del suero de leche con un hidróxido metálico básico para formar un precipitado que comprende calcio y fosfato y separar el precipitado del subproducto del suero de leche para proporcionar un subproducto del suero de leche clarificado. El subproducto del suero de leche clarificado es fermentado por una bacteria capaz de bioconvertir lactosa a ácido láctico para proporcionar un caldo de fermentación que contiene una sal de ácido láctico. En las etapas posteriores, el caldo de fermentación se acidifica para liberar el ácido láctico a partir de la sal de ácido láctico, el precipitado del caldo producido mediante acidificación se elimina y el caldo de fermentación acidificado se trata para recuperar ácido láctico puro mediante la eliminación de sales, agua y opcionalmente proteína residuales. El proceso de la invención produce ácido láctico que tiene una pureza de 80-98 % y |
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fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_MX2019001560A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MX2019001560A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_MX2019001560A3</originalsourceid><addsrcrecordid>eNrjZFB0VPB1DfHwd1Hwd1MICPJ3CXX29HNX8HF0DvF0VnB09nThYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxvhFGBoaWBgaGpmYGjsZEKQIAJn0iJQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>A METHOD OF PRODUCING LACTIC ACID</title><source>esp@cenet</source><creator>Magda HOGAN ; Eamon HOGAN ; Parikshit Rameshwar SAWDEKAR ; Bill MORRISSEY ; Ramesh Babu PADAMATI ; Colm O''BRIEN</creator><creatorcontrib>Magda HOGAN ; Eamon HOGAN ; Parikshit Rameshwar SAWDEKAR ; Bill MORRISSEY ; Ramesh Babu PADAMATI ; Colm O''BRIEN</creatorcontrib><description>A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate comprising calcium and phosphate, and separating the precipitate from the whey by-product to provide a clarified whey by-product. The clarified whey by-product is fermentated by a bacterium capable of bioconversion of lactose to lactic acid to provide a fermentation broth containing a lactic acid salt. In the downstream steps, the fermentation broth is acidified to release lactic acid from the lactic acid salt, precipitate from the broth produced by acidification is removed, and the acidified fermentation broth is treated to recover pure lactic acid by removal of residual salts, and water, and optionally protein. The process of the invention produces lactic acid having a purity of 80-98% and an isomeric purity of >98% L-lactic acid using a process that employs upstream removal of divalent salts by chemical precipitation, bacterial fermentation of the demineralised substrate, and minimum downstream processing of the fermentation broth. The methods of the invention may also be employed with milk permeates.
Se describe un proceso para producir ácido láctico puro a partir de un subproducto del suero de leche rico en lactosa y minerales, por ejemplo, permeado del suero de leche deslactosado o permeado del suero de leche concentrado. El método comprende etapas anteriores de neutralización del subproducto del suero de leche con un hidróxido metálico básico para formar un precipitado que comprende calcio y fosfato y separar el precipitado del subproducto del suero de leche para proporcionar un subproducto del suero de leche clarificado. El subproducto del suero de leche clarificado es fermentado por una bacteria capaz de bioconvertir lactosa a ácido láctico para proporcionar un caldo de fermentación que contiene una sal de ácido láctico. En las etapas posteriores, el caldo de fermentación se acidifica para liberar el ácido láctico a partir de la sal de ácido láctico, el precipitado del caldo producido mediante acidificación se elimina y el caldo de fermentación acidificado se trata para recuperar ácido láctico puro mediante la eliminación de sales, agua y opcionalmente proteína residuales. El proceso de la invención produce ácido láctico que tiene una pureza de 80-98 % y una pureza isomérica de >98 % de ácido L-láctico mediante el uso de un proceso que emplea una eliminación anterior de sales divalentes mediante precipitación química, fermentación bacteriana del sustrato desmineralizado y un procesamiento posterior mínimo del caldo de fermentación. Los métodos de la invención también pueden emplearse con permeados de leche.</description><language>eng ; spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; FOODS OR FOODSTUFFS ; HUMAN NECESSITIES ; MAKING THEREOF ; METALLURGY ; MICROBIOLOGY ; MILK OR CHEESE SUBSTITUTES ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; SEPARATION ; SPIRITS ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190918&DB=EPODOC&CC=MX&NR=2019001560A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190918&DB=EPODOC&CC=MX&NR=2019001560A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Magda HOGAN</creatorcontrib><creatorcontrib>Eamon HOGAN</creatorcontrib><creatorcontrib>Parikshit Rameshwar SAWDEKAR</creatorcontrib><creatorcontrib>Bill MORRISSEY</creatorcontrib><creatorcontrib>Ramesh Babu PADAMATI</creatorcontrib><creatorcontrib>Colm O''BRIEN</creatorcontrib><title>A METHOD OF PRODUCING LACTIC ACID</title><description>A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate comprising calcium and phosphate, and separating the precipitate from the whey by-product to provide a clarified whey by-product. The clarified whey by-product is fermentated by a bacterium capable of bioconversion of lactose to lactic acid to provide a fermentation broth containing a lactic acid salt. In the downstream steps, the fermentation broth is acidified to release lactic acid from the lactic acid salt, precipitate from the broth produced by acidification is removed, and the acidified fermentation broth is treated to recover pure lactic acid by removal of residual salts, and water, and optionally protein. The process of the invention produces lactic acid having a purity of 80-98% and an isomeric purity of >98% L-lactic acid using a process that employs upstream removal of divalent salts by chemical precipitation, bacterial fermentation of the demineralised substrate, and minimum downstream processing of the fermentation broth. The methods of the invention may also be employed with milk permeates.
Se describe un proceso para producir ácido láctico puro a partir de un subproducto del suero de leche rico en lactosa y minerales, por ejemplo, permeado del suero de leche deslactosado o permeado del suero de leche concentrado. El método comprende etapas anteriores de neutralización del subproducto del suero de leche con un hidróxido metálico básico para formar un precipitado que comprende calcio y fosfato y separar el precipitado del subproducto del suero de leche para proporcionar un subproducto del suero de leche clarificado. El subproducto del suero de leche clarificado es fermentado por una bacteria capaz de bioconvertir lactosa a ácido láctico para proporcionar un caldo de fermentación que contiene una sal de ácido láctico. En las etapas posteriores, el caldo de fermentación se acidifica para liberar el ácido láctico a partir de la sal de ácido láctico, el precipitado del caldo producido mediante acidificación se elimina y el caldo de fermentación acidificado se trata para recuperar ácido láctico puro mediante la eliminación de sales, agua y opcionalmente proteína residuales. El proceso de la invención produce ácido láctico que tiene una pureza de 80-98 % y una pureza isomérica de >98 % de ácido L-láctico mediante el uso de un proceso que emplea una eliminación anterior de sales divalentes mediante precipitación química, fermentación bacteriana del sustrato desmineralizado y un procesamiento posterior mínimo del caldo de fermentación. Los métodos de la invención también pueden emplearse con permeados de leche.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>FOODS OR FOODSTUFFS</subject><subject>HUMAN NECESSITIES</subject><subject>MAKING THEREOF</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MILK OR CHEESE SUBSTITUTES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>SEPARATION</subject><subject>SPIRITS</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB0VPB1DfHwd1Hwd1MICPJ3CXX29HNX8HF0DvF0VnB09nThYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxvhFGBoaWBgaGpmYGjsZEKQIAJn0iJQ</recordid><startdate>20190918</startdate><enddate>20190918</enddate><creator>Magda HOGAN</creator><creator>Eamon HOGAN</creator><creator>Parikshit Rameshwar SAWDEKAR</creator><creator>Bill MORRISSEY</creator><creator>Ramesh Babu PADAMATI</creator><creator>Colm O''BRIEN</creator><scope>EVB</scope></search><sort><creationdate>20190918</creationdate><title>A METHOD OF PRODUCING LACTIC ACID</title><author>Magda HOGAN ; Eamon HOGAN ; Parikshit Rameshwar SAWDEKAR ; Bill MORRISSEY ; Ramesh Babu PADAMATI ; Colm O''BRIEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2019001560A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>FOODS OR FOODSTUFFS</topic><topic>HUMAN NECESSITIES</topic><topic>MAKING THEREOF</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MILK OR CHEESE SUBSTITUTES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>SEPARATION</topic><topic>SPIRITS</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Magda HOGAN</creatorcontrib><creatorcontrib>Eamon HOGAN</creatorcontrib><creatorcontrib>Parikshit Rameshwar SAWDEKAR</creatorcontrib><creatorcontrib>Bill MORRISSEY</creatorcontrib><creatorcontrib>Ramesh Babu PADAMATI</creatorcontrib><creatorcontrib>Colm O''BRIEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Magda HOGAN</au><au>Eamon HOGAN</au><au>Parikshit Rameshwar SAWDEKAR</au><au>Bill MORRISSEY</au><au>Ramesh Babu PADAMATI</au><au>Colm O''BRIEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A METHOD OF PRODUCING LACTIC ACID</title><date>2019-09-18</date><risdate>2019</risdate><abstract>A process for producing pure lactic acid from a whey by-product rich in lactose and minerals, for example delactosed why permeate or concentrated whey permeate, is described. The method comprises upstream steps of neutralising the whey by-product with a basic metal hydroxide to form a precipitate comprising calcium and phosphate, and separating the precipitate from the whey by-product to provide a clarified whey by-product. The clarified whey by-product is fermentated by a bacterium capable of bioconversion of lactose to lactic acid to provide a fermentation broth containing a lactic acid salt. In the downstream steps, the fermentation broth is acidified to release lactic acid from the lactic acid salt, precipitate from the broth produced by acidification is removed, and the acidified fermentation broth is treated to recover pure lactic acid by removal of residual salts, and water, and optionally protein. The process of the invention produces lactic acid having a purity of 80-98% and an isomeric purity of >98% L-lactic acid using a process that employs upstream removal of divalent salts by chemical precipitation, bacterial fermentation of the demineralised substrate, and minimum downstream processing of the fermentation broth. The methods of the invention may also be employed with milk permeates.
Se describe un proceso para producir ácido láctico puro a partir de un subproducto del suero de leche rico en lactosa y minerales, por ejemplo, permeado del suero de leche deslactosado o permeado del suero de leche concentrado. El método comprende etapas anteriores de neutralización del subproducto del suero de leche con un hidróxido metálico básico para formar un precipitado que comprende calcio y fosfato y separar el precipitado del subproducto del suero de leche para proporcionar un subproducto del suero de leche clarificado. El subproducto del suero de leche clarificado es fermentado por una bacteria capaz de bioconvertir lactosa a ácido láctico para proporcionar un caldo de fermentación que contiene una sal de ácido láctico. En las etapas posteriores, el caldo de fermentación se acidifica para liberar el ácido láctico a partir de la sal de ácido láctico, el precipitado del caldo producido mediante acidificación se elimina y el caldo de fermentación acidificado se trata para recuperar ácido láctico puro mediante la eliminación de sales, agua y opcionalmente proteína residuales. El proceso de la invención produce ácido láctico que tiene una pureza de 80-98 % y una pureza isomérica de >98 % de ácido L-láctico mediante el uso de un proceso que emplea una eliminación anterior de sales divalentes mediante precipitación química, fermentación bacteriana del sustrato desmineralizado y un procesamiento posterior mínimo del caldo de fermentación. Los métodos de la invención también pueden emplearse con permeados de leche.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FOODS OR FOODSTUFFS HUMAN NECESSITIES MAKING THEREOF METALLURGY MICROBIOLOGY MILK OR CHEESE SUBSTITUTES MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION SPIRITS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRANSPORTING VINEGAR WINE |
title | A METHOD OF PRODUCING LACTIC ACID |
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