PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER
The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical use...
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| creator | Chan- Jung LI David Chih- Kuang CHOU Shin TSAI JR Yu- En TIEN Shu- Wen KUO Jin- Ding HUANG |
| description | The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
La presente invención de relaciona a formulaciones farmacéuticas, de liberación prolongada, inyectables, que comprenden un profármaco de éster de nalbufina homogéneamente disuelto en una solución que comprende un aceite farmacéuticamente aceptable y un solvente de retención miscible en aceite, así como procesos de manufactura y usos médicos de las formulaciones. La invención además proporciona métodos para ajustar la duración de acción de las formulaciones al variar la relación del aceite farmacéuticamente aceptable y el solvente de retención miscible en aceite. |
| format | Patent |
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La presente invención de relaciona a formulaciones farmacéuticas, de liberación prolongada, inyectables, que comprenden un profármaco de éster de nalbufina homogéneamente disuelto en una solución que comprende un aceite farmacéuticamente aceptable y un solvente de retención miscible en aceite, así como procesos de manufactura y usos médicos de las formulaciones. La invención además proporciona métodos para ajustar la duración de acción de las formulaciones al variar la relación del aceite farmacéuticamente aceptable y el solvente de retención miscible en aceite.</description><language>eng ; spa</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180328&DB=EPODOC&CC=MX&NR=2017015138A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180328&DB=EPODOC&CC=MX&NR=2017015138A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Chan- Jung LI</creatorcontrib><creatorcontrib>David Chih- Kuang CHOU</creatorcontrib><creatorcontrib>Shin TSAI JR</creatorcontrib><creatorcontrib>Yu- En TIEN</creatorcontrib><creatorcontrib>Shu- Wen KUO</creatorcontrib><creatorcontrib>Jin- Ding HUANG</creatorcontrib><title>PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER</title><description>The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
La presente invención de relaciona a formulaciones farmacéuticas, de liberación prolongada, inyectables, que comprenden un profármaco de éster de nalbufina homogéneamente disuelto en una solución que comprende un aceite farmacéuticamente aceptable y un solvente de retención miscible en aceite, así como procesos de manufactura y usos médicos de las formulaciones. La invención además proporciona métodos para ajustar la duración de acción de las formulaciones al variar la relación del aceite farmacéuticamente aceptable y el solvente de retención miscible en aceite.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrsKwjAUgOEsDqK-w8FdaCyi62l6QgK5kQvoVIrESbRQ3x8VfACnnx--JQtBYbQoqGQt0ID00RaDWXuXvgOppIzaUQ-RDGEi8BISdSj8xUCvHZquBPURQClTXLPFbbzPdfPrim0lZaF2dXoOdZ7Ga33U12DP-4YfG37g7Qnbv9Ab_dUv1A</recordid><startdate>20180328</startdate><enddate>20180328</enddate><creator>Chan- Jung LI</creator><creator>David Chih- Kuang CHOU</creator><creator>Shin TSAI JR</creator><creator>Yu- En TIEN</creator><creator>Shu- Wen KUO</creator><creator>Jin- Ding HUANG</creator><scope>EVB</scope></search><sort><creationdate>20180328</creationdate><title>PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER</title><author>Chan- Jung LI ; David Chih- Kuang CHOU ; Shin TSAI JR ; Yu- En TIEN ; Shu- Wen KUO ; Jin- Ding HUANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2017015138A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Chan- Jung LI</creatorcontrib><creatorcontrib>David Chih- Kuang CHOU</creatorcontrib><creatorcontrib>Shin TSAI JR</creatorcontrib><creatorcontrib>Yu- En TIEN</creatorcontrib><creatorcontrib>Shu- Wen KUO</creatorcontrib><creatorcontrib>Jin- Ding HUANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chan- Jung LI</au><au>David Chih- Kuang CHOU</au><au>Shin TSAI JR</au><au>Yu- En TIEN</au><au>Shu- Wen KUO</au><au>Jin- Ding HUANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER</title><date>2018-03-28</date><risdate>2018</risdate><abstract>The present invention relates to injectable, extended-release, pharmaceutical formulations comprising a nalbuphine ester prodrug homogenously dissolved in a solution comprising a pharmaceutically acceptable oil and an oil-miscible retaining solvent, as well as manufacturing processes and medical uses of the formulations. The invention further provides methods for adjusting the duration of action of the formulations by varying the ratio of the pharmaceutically acceptable oil and the oil-miscible retaining solvent.
La presente invención de relaciona a formulaciones farmacéuticas, de liberación prolongada, inyectables, que comprenden un profármaco de éster de nalbufina homogéneamente disuelto en una solución que comprende un aceite farmacéuticamente aceptable y un solvente de retención miscible en aceite, así como procesos de manufactura y usos médicos de las formulaciones. La invención además proporciona métodos para ajustar la duración de acción de las formulaciones al variar la relación del aceite farmacéuticamente aceptable y el solvente de retención miscible en aceite.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE OF SEBACOYL DINALBUPHINE ESTER |
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