5'-SUBSTITUTED NUCLEOSIDE ANALOGS

The present invention relates to novel 5-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancrea...

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Hauptverfasser: Karl Robert DAHNKE, James Andrew JAMISON, Brian Morgan WATSON, Zahid Quyoom BONDAY, Antonio RODRIGUEZ HERGUETA, Guillermo S. CORTEZ, Michael John GROGAN, Timothy Andrew WOODS
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creator Karl Robert DAHNKE
James Andrew JAMISON
Brian Morgan WATSON
Zahid Quyoom BONDAY
Antonio RODRIGUEZ HERGUETA
Guillermo S. CORTEZ
Michael John GROGAN
Timothy Andrew WOODS
description The present invention relates to novel 5-substituted nucleoside compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer, in particular glioblastomas, melanoma, sarcomas, gastric cancer, pancreatic cancer, cholangiocarcinoma, bladder cancer, breast cancer, non-small cell lung cancer, leukemias including acute myeloid leukemia, and lymphomas. La presente invención se refiere a compuestos de nucleósidos. 5'-sustituidos novedosos, composiciones farmacéuticas que comprenden los compuestos y métodos de utilización de los compuestos para tratar el cáncer, más particularmente para el tratamiento del cáncer, en particular los glioblastomas, melanoma, sarcomas, cáncer gástrico, cáncer de páncreas, colangiocarcinoma, cáncer de vejiga, cáncer de mama, cáncer de pulmón de células no pequeñas, leucemias, incluyendo leucemia mieloide aguda y los linfomas.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 5'-SUBSTITUTED NUCLEOSIDE ANALOGS
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