5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
The present invention discloses compounds according to Formula (I), wherein R, R2, R3a, R3b, and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or...
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| creator | Luke Jonathan ALVEY David AMANTINI Iuliana Ecaterina POP-BOTEZ Pierre Marc Marie Joseph DEPREZ Marie Laurence Clare VARIN Romain Luc Marie GOSMINI Helène Marie JARY Franck Laurent BREBION Christophe PEIXOTO Frédéric André DE CEUNINCK |
| description | The present invention discloses compounds according to Formula (I), wherein R, R2, R3a, R3b, and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.
La presente invención describe compuestos de acuerdo con la Fórmula I: (ver formula) donde R', R2, R3a, R3b, y Cy son como se define en la presente descripción. La presente invención se refiere a compuestos para inhibir ADAMTS, métodos para su producción, composiciones farmacéuticas que comprenden las mismas y métodos de tratamiento utilizando las mismas, para la profilaxis y/o el tratamiento de las condiciones inflamatorias y/o de las enfermedades que involucran la degradación del cartílago y/o la interrupción de la homeostasis del cartílago, administrando un compuesto de la invención. |
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La presente invención describe compuestos de acuerdo con la Fórmula I: (ver formula) donde R', R2, R3a, R3b, y Cy son como se define en la presente descripción. La presente invención se refiere a compuestos para inhibir ADAMTS, métodos para su producción, composiciones farmacéuticas que comprenden las mismas y métodos de tratamiento utilizando las mismas, para la profilaxis y/o el tratamiento de las condiciones inflamatorias y/o de las enfermedades que involucran la degradación del cartílago y/o la interrupción de la homeostasis del cartílago, administrando un compuesto de la invención.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171019&DB=EPODOC&CC=MX&NR=2017008048A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171019&DB=EPODOC&CC=MX&NR=2017008048A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Luke Jonathan ALVEY</creatorcontrib><creatorcontrib>David AMANTINI</creatorcontrib><creatorcontrib>Iuliana Ecaterina POP-BOTEZ</creatorcontrib><creatorcontrib>Pierre Marc Marie Joseph DEPREZ</creatorcontrib><creatorcontrib>Marie Laurence Clare VARIN</creatorcontrib><creatorcontrib>Romain Luc Marie GOSMINI</creatorcontrib><creatorcontrib>Helène Marie JARY</creatorcontrib><creatorcontrib>Franck Laurent BREBION</creatorcontrib><creatorcontrib>Christophe PEIXOTO</creatorcontrib><creatorcontrib>Frédéric André DE CEUNINCK</creatorcontrib><title>5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS</title><description>The present invention discloses compounds according to Formula (I), wherein R, R2, R3a, R3b, and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.
La presente invención describe compuestos de acuerdo con la Fórmula I: (ver formula) donde R', R2, R3a, R3b, y Cy son como se define en la presente descripción. La presente invención se refiere a compuestos para inhibir ADAMTS, métodos para su producción, composiciones farmacéuticas que comprenden las mismas y métodos de tratamiento utilizando las mismas, para la profilaxis y/o el tratamiento de las condiciones inflamatorias y/o de las enfermedades que involucran la degradación del cartílago y/o la interrupción de la homeostasis del cartílago, administrando un compuesto de la invención.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyj0KwkAQQOE0FqLeYbFScCB_ou3qTshAshN2h5AoIiJrJSpo7dm18ADCg695w-i9hP2soQad3pGFBPpqDhlwx9A4bvrqAFST0TuuyJBFSBc5GGKLyqCjVgu16JX-ZnQtXpEtaUPCzquCnZISlTjUUqMVxYViL8jaSelIyI-jweV0fYbJz1E0LVC2JYTH_Riej9M53MLrWHdpnKzieB3na539NX0AS9M8HA</recordid><startdate>20171019</startdate><enddate>20171019</enddate><creator>Luke Jonathan ALVEY</creator><creator>David AMANTINI</creator><creator>Iuliana Ecaterina POP-BOTEZ</creator><creator>Pierre Marc Marie Joseph DEPREZ</creator><creator>Marie Laurence Clare VARIN</creator><creator>Romain Luc Marie GOSMINI</creator><creator>Helène Marie JARY</creator><creator>Franck Laurent BREBION</creator><creator>Christophe PEIXOTO</creator><creator>Frédéric André DE CEUNINCK</creator><scope>EVB</scope></search><sort><creationdate>20171019</creationdate><title>5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS</title><author>Luke Jonathan ALVEY ; David AMANTINI ; Iuliana Ecaterina POP-BOTEZ ; Pierre Marc Marie Joseph DEPREZ ; Marie Laurence Clare VARIN ; Romain Luc Marie GOSMINI ; Helène Marie JARY ; Franck Laurent BREBION ; Christophe PEIXOTO ; Frédéric André DE CEUNINCK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2017008048A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Luke Jonathan ALVEY</creatorcontrib><creatorcontrib>David AMANTINI</creatorcontrib><creatorcontrib>Iuliana Ecaterina POP-BOTEZ</creatorcontrib><creatorcontrib>Pierre Marc Marie Joseph DEPREZ</creatorcontrib><creatorcontrib>Marie Laurence Clare VARIN</creatorcontrib><creatorcontrib>Romain Luc Marie GOSMINI</creatorcontrib><creatorcontrib>Helène Marie JARY</creatorcontrib><creatorcontrib>Franck Laurent BREBION</creatorcontrib><creatorcontrib>Christophe PEIXOTO</creatorcontrib><creatorcontrib>Frédéric André DE CEUNINCK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Luke Jonathan ALVEY</au><au>David AMANTINI</au><au>Iuliana Ecaterina POP-BOTEZ</au><au>Pierre Marc Marie Joseph DEPREZ</au><au>Marie Laurence Clare VARIN</au><au>Romain Luc Marie GOSMINI</au><au>Helène Marie JARY</au><au>Franck Laurent BREBION</au><au>Christophe PEIXOTO</au><au>Frédéric André DE CEUNINCK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS</title><date>2017-10-19</date><risdate>2017</risdate><abstract>The present invention discloses compounds according to Formula (I), wherein R, R2, R3a, R3b, and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.
La presente invención describe compuestos de acuerdo con la Fórmula I: (ver formula) donde R', R2, R3a, R3b, y Cy son como se define en la presente descripción. La presente invención se refiere a compuestos para inhibir ADAMTS, métodos para su producción, composiciones farmacéuticas que comprenden las mismas y métodos de tratamiento utilizando las mismas, para la profilaxis y/o el tratamiento de las condiciones inflamatorias y/o de las enfermedades que involucran la degradación del cartílago y/o la interrupción de la homeostasis del cartílago, administrando un compuesto de la invención.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS |
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