HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS
The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant or...
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| creator | HUI XIONG SHANTA BIST BOLIN GENG BRENDAN CHEN DAEMIAN DAVID DUSSAULT JANELLE COMITA-PREVOIR THOMAS DURAND-REVILLE YE WU SATENIG GULER HOAN HUYNH NEIL BIFULCO HELEN MAUREEN MCGUIRE LIANG ZHAO |
| description | The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R 2, R 3 and R 4 are described herein.
La presente invención se refiere a compuestos que son inhibidores de beta-lactamasas. Los compuestos y sus sales farmacéuticamente aceptables son útiles combinados con antibióticos beta-lactámicos o solos para el tratamiento de infecciones bacterianas, incluidas las infecciones provocadas por organismos resistentes a fármacos, incluidos los organismos resistentes a múltiples fármacos. La presente invención incluye compuestos de conformidad con la Fórmula (Ia) (ver Fórmula) o una de sus sales farmacéuticamente aceptables, donde los valores de R1, R2, R3 y R4 son como se describen en la presente. |
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La presente invención se refiere a compuestos que son inhibidores de beta-lactamasas. Los compuestos y sus sales farmacéuticamente aceptables son útiles combinados con antibióticos beta-lactámicos o solos para el tratamiento de infecciones bacterianas, incluidas las infecciones provocadas por organismos resistentes a fármacos, incluidos los organismos resistentes a múltiples fármacos. La presente invención incluye compuestos de conformidad con la Fórmula (Ia) (ver Fórmula) o una de sus sales farmacéuticamente aceptables, donde los valores de R1, R2, R3 y R4 son como se describen en la presente.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141205&DB=EPODOC&CC=MX&NR=2014011351A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141205&DB=EPODOC&CC=MX&NR=2014011351A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUI XIONG</creatorcontrib><creatorcontrib>SHANTA BIST</creatorcontrib><creatorcontrib>BOLIN GENG</creatorcontrib><creatorcontrib>BRENDAN CHEN</creatorcontrib><creatorcontrib>DAEMIAN DAVID DUSSAULT</creatorcontrib><creatorcontrib>JANELLE COMITA-PREVOIR</creatorcontrib><creatorcontrib>THOMAS DURAND-REVILLE</creatorcontrib><creatorcontrib>YE WU</creatorcontrib><creatorcontrib>SATENIG GULER</creatorcontrib><creatorcontrib>HOAN HUYNH</creatorcontrib><creatorcontrib>NEIL BIFULCO</creatorcontrib><creatorcontrib>HELEN MAUREEN MCGUIRE</creatorcontrib><creatorcontrib>LIANG ZHAO</creatorcontrib><title>HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS</title><description>The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R 2, R 3 and R 4 are described herein.
La presente invención se refiere a compuestos que son inhibidores de beta-lactamasas. Los compuestos y sus sales farmacéuticamente aceptables son útiles combinados con antibióticos beta-lactámicos o solos para el tratamiento de infecciones bacterianas, incluidas las infecciones provocadas por organismos resistentes a fármacos, incluidos los organismos resistentes a múltiples fármacos. La presente invención incluye compuestos de conformidad con la Fórmula (Ia) (ver Fórmula) o una de sus sales farmacéuticamente aceptables, donde los valores de R1, R2, R3 y R4 son como se describen en la presente.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD1cA1xDfJ38nSOdPbxdFZw9vcN8A_1cwlWcAxWcHINcdT1cXQOcfR1DHZV8PTz8HTyDPEPCuZhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfG-EUYGhiYGhobGpoaOxkQpAgBJLCgu</recordid><startdate>20141205</startdate><enddate>20141205</enddate><creator>HUI XIONG</creator><creator>SHANTA BIST</creator><creator>BOLIN GENG</creator><creator>BRENDAN CHEN</creator><creator>DAEMIAN DAVID DUSSAULT</creator><creator>JANELLE COMITA-PREVOIR</creator><creator>THOMAS DURAND-REVILLE</creator><creator>YE WU</creator><creator>SATENIG GULER</creator><creator>HOAN HUYNH</creator><creator>NEIL BIFULCO</creator><creator>HELEN MAUREEN MCGUIRE</creator><creator>LIANG ZHAO</creator><scope>EVB</scope></search><sort><creationdate>20141205</creationdate><title>HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS</title><author>HUI XIONG ; SHANTA BIST ; BOLIN GENG ; BRENDAN CHEN ; DAEMIAN DAVID DUSSAULT ; JANELLE COMITA-PREVOIR ; THOMAS DURAND-REVILLE ; YE WU ; SATENIG GULER ; HOAN HUYNH ; NEIL BIFULCO ; HELEN MAUREEN MCGUIRE ; LIANG ZHAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2014011351A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HUI XIONG</creatorcontrib><creatorcontrib>SHANTA BIST</creatorcontrib><creatorcontrib>BOLIN GENG</creatorcontrib><creatorcontrib>BRENDAN CHEN</creatorcontrib><creatorcontrib>DAEMIAN DAVID DUSSAULT</creatorcontrib><creatorcontrib>JANELLE COMITA-PREVOIR</creatorcontrib><creatorcontrib>THOMAS DURAND-REVILLE</creatorcontrib><creatorcontrib>YE WU</creatorcontrib><creatorcontrib>SATENIG GULER</creatorcontrib><creatorcontrib>HOAN HUYNH</creatorcontrib><creatorcontrib>NEIL BIFULCO</creatorcontrib><creatorcontrib>HELEN MAUREEN MCGUIRE</creatorcontrib><creatorcontrib>LIANG ZHAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HUI XIONG</au><au>SHANTA BIST</au><au>BOLIN GENG</au><au>BRENDAN CHEN</au><au>DAEMIAN DAVID DUSSAULT</au><au>JANELLE COMITA-PREVOIR</au><au>THOMAS DURAND-REVILLE</au><au>YE WU</au><au>SATENIG GULER</au><au>HOAN HUYNH</au><au>NEIL BIFULCO</au><au>HELEN MAUREEN MCGUIRE</au><au>LIANG ZHAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS</title><date>2014-12-05</date><risdate>2014</risdate><abstract>The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R 2, R 3 and R 4 are described herein.
La presente invención se refiere a compuestos que son inhibidores de beta-lactamasas. Los compuestos y sus sales farmacéuticamente aceptables son útiles combinados con antibióticos beta-lactámicos o solos para el tratamiento de infecciones bacterianas, incluidas las infecciones provocadas por organismos resistentes a fármacos, incluidos los organismos resistentes a múltiples fármacos. La presente invención incluye compuestos de conformidad con la Fórmula (Ia) (ver Fórmula) o una de sus sales farmacéuticamente aceptables, donde los valores de R1, R2, R3 y R4 son como se describen en la presente.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS |
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