CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF
The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the inven...
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| creator | RAO, JAGANNATH MADANAHALLI RANGANATH DOPPALAPUDI, SIVANAGESWARA RAO BABU, NARESH M P S PRADEEP, JIDUGU ARUMUGAM, NAGARAJAN KOTTAMALAI, RAMAMOORTHY ANSARI, MOHAMMED GNANAVEL, S RAJ, AUGUSTINE MICHAEL GEORGE, JENSON KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI ALLAVUDDEEN, SULTHAN VIJAYARAMALINGAM, K VENKATESHAM, UPPALA PRASAD, HAMPELINGAIAH SHIVA MURUGAVEL, K FERNAND, GEORGE MADHAVAN, G R |
| description | The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
La presente invención se relaciona a ciertos derivados de amida que tienen la capacidad para inhibir 11-ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD-1) y las cuales son por lo tanto útiles en el tratamiento de ciertos trastornos que pueden prevenirse o tratarse por medio de la inhibición de esta enzima. Además, la invención se relaciona a compuestos, métodos para su preparación, composiciones farmacéuticas que contienen los compuestos y los usos de estos compuestos en el tratamiento de ciertos trastornos. Se espera que los compuestos de la invención encontrará aplicación en el tratamiento de condiciones tales como diabetes mellitus tipo 2 no dependiente a la insulina (NIDDM), resistencia a la insulina, obesidad, glucosa en ayuno disminuida, tolerancia a la glucosa disminuida, trastornos de lípidos tales como dislipidemia, hipertensión y así como otras enfermedades y condiciones. |
| format | Patent |
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La presente invención se relaciona a ciertos derivados de amida que tienen la capacidad para inhibir 11-ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD-1) y las cuales son por lo tanto útiles en el tratamiento de ciertos trastornos que pueden prevenirse o tratarse por medio de la inhibición de esta enzima. Además, la invención se relaciona a compuestos, métodos para su preparación, composiciones farmacéuticas que contienen los compuestos y los usos de estos compuestos en el tratamiento de ciertos trastornos. Se espera que los compuestos de la invención encontrará aplicación en el tratamiento de condiciones tales como diabetes mellitus tipo 2 no dependiente a la insulina (NIDDM), resistencia a la insulina, obesidad, glucosa en ayuno disminuida, tolerancia a la glucosa disminuida, trastornos de lípidos tales como dislipidemia, hipertensión y así como otras enfermedades y condiciones.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150319&DB=EPODOC&CC=MX&NR=2014007719A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150319&DB=EPODOC&CC=MX&NR=2014007719A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAO, JAGANNATH MADANAHALLI RANGANATH</creatorcontrib><creatorcontrib>DOPPALAPUDI, SIVANAGESWARA RAO</creatorcontrib><creatorcontrib>BABU, NARESH M P S</creatorcontrib><creatorcontrib>PRADEEP, JIDUGU</creatorcontrib><creatorcontrib>ARUMUGAM, NAGARAJAN</creatorcontrib><creatorcontrib>KOTTAMALAI, RAMAMOORTHY</creatorcontrib><creatorcontrib>ANSARI, MOHAMMED</creatorcontrib><creatorcontrib>GNANAVEL, S</creatorcontrib><creatorcontrib>RAJ, AUGUSTINE MICHAEL</creatorcontrib><creatorcontrib>GEORGE, JENSON</creatorcontrib><creatorcontrib>KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI</creatorcontrib><creatorcontrib>ALLAVUDDEEN, SULTHAN</creatorcontrib><creatorcontrib>VIJAYARAMALINGAM, K</creatorcontrib><creatorcontrib>VENKATESHAM, UPPALA</creatorcontrib><creatorcontrib>PRASAD, HAMPELINGAIAH SHIVA</creatorcontrib><creatorcontrib>MURUGAVEL, K</creatorcontrib><creatorcontrib>FERNAND, GEORGE</creatorcontrib><creatorcontrib>MADHAVAN, G R</creatorcontrib><title>CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF</title><description>The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
La presente invención se relaciona a ciertos derivados de amida que tienen la capacidad para inhibir 11-ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD-1) y las cuales son por lo tanto útiles en el tratamiento de ciertos trastornos que pueden prevenirse o tratarse por medio de la inhibición de esta enzima. Además, la invención se relaciona a compuestos, métodos para su preparación, composiciones farmacéuticas que contienen los compuestos y los usos de estos compuestos en el tratamiento de ciertos trastornos. Se espera que los compuestos de la invención encontrará aplicación en el tratamiento de condiciones tales como diabetes mellitus tipo 2 no dependiente a la insulina (NIDDM), resistencia a la insulina, obesidad, glucosa en ayuno disminuida, tolerancia a la glucosa disminuida, trastornos de lípidos tales como dislipidemia, hipertensión y así como otras enfermedades y condiciones.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeodBveFRIXicppMzYBtIImlXZVS4kq0UO-PQTyAqwef9986m1SvrqwAa9YEmhy3GLglD-iBG8MlB-s82AqkhBxKCphgeu1s1_tAzrJOv-9woQY9ATYabj4lgiFHttpmq_v4WOLux022rygok8f5NcRlHqf4jO-h7g5CnoQoCnnG41_SBx-fNB4</recordid><startdate>20150319</startdate><enddate>20150319</enddate><creator>RAO, JAGANNATH MADANAHALLI RANGANATH</creator><creator>DOPPALAPUDI, SIVANAGESWARA RAO</creator><creator>BABU, NARESH M P S</creator><creator>PRADEEP, JIDUGU</creator><creator>ARUMUGAM, NAGARAJAN</creator><creator>KOTTAMALAI, RAMAMOORTHY</creator><creator>ANSARI, MOHAMMED</creator><creator>GNANAVEL, S</creator><creator>RAJ, AUGUSTINE MICHAEL</creator><creator>GEORGE, JENSON</creator><creator>KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI</creator><creator>ALLAVUDDEEN, SULTHAN</creator><creator>VIJAYARAMALINGAM, K</creator><creator>VENKATESHAM, UPPALA</creator><creator>PRASAD, HAMPELINGAIAH SHIVA</creator><creator>MURUGAVEL, K</creator><creator>FERNAND, GEORGE</creator><creator>MADHAVAN, G R</creator><scope>EVB</scope></search><sort><creationdate>20150319</creationdate><title>CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF</title><author>RAO, JAGANNATH MADANAHALLI RANGANATH ; 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In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
La presente invención se relaciona a ciertos derivados de amida que tienen la capacidad para inhibir 11-ß-hidroxiesteroide deshidrogenasa tipo 1 (11ß-HSD-1) y las cuales son por lo tanto útiles en el tratamiento de ciertos trastornos que pueden prevenirse o tratarse por medio de la inhibición de esta enzima. Además, la invención se relaciona a compuestos, métodos para su preparación, composiciones farmacéuticas que contienen los compuestos y los usos de estos compuestos en el tratamiento de ciertos trastornos. Se espera que los compuestos de la invención encontrará aplicación en el tratamiento de condiciones tales como diabetes mellitus tipo 2 no dependiente a la insulina (NIDDM), resistencia a la insulina, obesidad, glucosa en ayuno disminuida, tolerancia a la glucosa disminuida, trastornos de lípidos tales como dislipidemia, hipertensión y así como otras enfermedades y condiciones.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF |
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