FRAGMENTATION RESISTANT IgG1 Fc-CONJUGATES

FRAGMENTATION RESISTANT IgG1 Fc-CONJUGATES

The present invention provides compositions and methods relating to human IgG1 and IgG3 Fc-conjugates which are resistant to free-radical mediated fragmentation and aggregation. The present invention also provides compositions and methods for making the Fc-conjugates of the invention. La presente in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHONGHUA HU, HONGXING ZHOU, BOXU YAN, GERD RICHARD KLEEMANN, ZACHARY ADAM YATES
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides compositions and methods relating to human IgG1 and IgG3 Fc-conjugates which are resistant to free-radical mediated fragmentation and aggregation. The present invention also provides compositions and methods for making the Fc-conjugates of the invention. La presente invención proporciona composiciones y métodos que se refieren a los conjugados de Fc de IgG1 e IgG3 que son resistentes a la fragmentación y la agregación mediadas por radicales libres. La presente invención también proporciona composiciones y métodos para fabricar los conjugados de Fc de la invención.