SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF
The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or prevent...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; spa |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | JIAN LIN BRIAN ALAN LANMAN KIMBERLEY GANNON ZHAODA ZHANG XIANG Y. YU ASHIS SAHA SRINIVASA R. CHERUKU ROBERT C. PENLAND PINI ORBACH SHARON SHACHAM OREN BECKER SUSANA NEIRA DILARA MCCAULEY SILVIA NOIMAN NILI SCHUTZ ANURAG SHARADENDU JENNIFER GOLDEN MERCEDES LOBERA VICTOR J. CEE ROLAND BURLI |
| description | The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
La presente invención se refiere a compuestos de la fórmula general (I) que tienen actividad como agentes moduladores del receptor de S1P y al uso de estos compuestos para tratar enfermedades asociadas con actividad inadecuada del receptor de S1P. Los compuestos pueden usarse como inmunomoduladores, por ejemplo, para tratar o prevenir enfermedades tales como trastornos autoinmunes e inmunitarios relacionados incluyendo lupus eritematoso sistémico, enfermedades inflamatorias del intestino tales como enferedad de Crohn y colitis ulcerosa, diabetes tipo I, uveítis, psoriasis, maistenia grave, artritis reumatoide, nefrosis no glomerular, hepatitis, enfermedad de Behcet, glomerulonefritis, púrpura trombocitopénica crónica, anemia hemolítica, hepatitis y granuloma de Wegner; y para tratar otras afecciones. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_MX2009010060A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MX2009010060A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_MX2009010060A3</originalsourceid><addsrcrecordid>eNrjZDAM9gxQCHJ1dg0I8Q9S8PV3CfVxDPH0c1dw9vcN8A_1cwlWcPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8b4RRgYGlgaGBgZmBo7GRCkCAKuuJw8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF</title><source>esp@cenet</source><creator>JIAN LIN ; BRIAN ALAN LANMAN ; KIMBERLEY GANNON ; ZHAODA ZHANG ; XIANG Y. YU ; ASHIS SAHA ; SRINIVASA R. CHERUKU ; ROBERT C. PENLAND ; PINI ORBACH ; SHARON SHACHAM ; OREN BECKER ; SUSANA NEIRA ; DILARA MCCAULEY ; SILVIA NOIMAN ; NILI SCHUTZ ; ANURAG SHARADENDU ; JENNIFER GOLDEN ; MERCEDES LOBERA ; VICTOR J. CEE ; ROLAND BURLI</creator><creatorcontrib>JIAN LIN ; BRIAN ALAN LANMAN ; KIMBERLEY GANNON ; ZHAODA ZHANG ; XIANG Y. YU ; ASHIS SAHA ; SRINIVASA R. CHERUKU ; ROBERT C. PENLAND ; PINI ORBACH ; SHARON SHACHAM ; OREN BECKER ; SUSANA NEIRA ; DILARA MCCAULEY ; SILVIA NOIMAN ; NILI SCHUTZ ; ANURAG SHARADENDU ; JENNIFER GOLDEN ; MERCEDES LOBERA ; VICTOR J. CEE ; ROLAND BURLI</creatorcontrib><description>The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
La presente invención se refiere a compuestos de la fórmula general (I) que tienen actividad como agentes moduladores del receptor de S1P y al uso de estos compuestos para tratar enfermedades asociadas con actividad inadecuada del receptor de S1P. Los compuestos pueden usarse como inmunomoduladores, por ejemplo, para tratar o prevenir enfermedades tales como trastornos autoinmunes e inmunitarios relacionados incluyendo lupus eritematoso sistémico, enfermedades inflamatorias del intestino tales como enferedad de Crohn y colitis ulcerosa, diabetes tipo I, uveítis, psoriasis, maistenia grave, artritis reumatoide, nefrosis no glomerular, hepatitis, enfermedad de Behcet, glomerulonefritis, púrpura trombocitopénica crónica, anemia hemolítica, hepatitis y granuloma de Wegner; y para tratar otras afecciones.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100120&DB=EPODOC&CC=MX&NR=2009010060A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100120&DB=EPODOC&CC=MX&NR=2009010060A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIAN LIN</creatorcontrib><creatorcontrib>BRIAN ALAN LANMAN</creatorcontrib><creatorcontrib>KIMBERLEY GANNON</creatorcontrib><creatorcontrib>ZHAODA ZHANG</creatorcontrib><creatorcontrib>XIANG Y. YU</creatorcontrib><creatorcontrib>ASHIS SAHA</creatorcontrib><creatorcontrib>SRINIVASA R. CHERUKU</creatorcontrib><creatorcontrib>ROBERT C. PENLAND</creatorcontrib><creatorcontrib>PINI ORBACH</creatorcontrib><creatorcontrib>SHARON SHACHAM</creatorcontrib><creatorcontrib>OREN BECKER</creatorcontrib><creatorcontrib>SUSANA NEIRA</creatorcontrib><creatorcontrib>DILARA MCCAULEY</creatorcontrib><creatorcontrib>SILVIA NOIMAN</creatorcontrib><creatorcontrib>NILI SCHUTZ</creatorcontrib><creatorcontrib>ANURAG SHARADENDU</creatorcontrib><creatorcontrib>JENNIFER GOLDEN</creatorcontrib><creatorcontrib>MERCEDES LOBERA</creatorcontrib><creatorcontrib>VICTOR J. CEE</creatorcontrib><creatorcontrib>ROLAND BURLI</creatorcontrib><title>SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF</title><description>The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
La presente invención se refiere a compuestos de la fórmula general (I) que tienen actividad como agentes moduladores del receptor de S1P y al uso de estos compuestos para tratar enfermedades asociadas con actividad inadecuada del receptor de S1P. Los compuestos pueden usarse como inmunomoduladores, por ejemplo, para tratar o prevenir enfermedades tales como trastornos autoinmunes e inmunitarios relacionados incluyendo lupus eritematoso sistémico, enfermedades inflamatorias del intestino tales como enferedad de Crohn y colitis ulcerosa, diabetes tipo I, uveítis, psoriasis, maistenia grave, artritis reumatoide, nefrosis no glomerular, hepatitis, enfermedad de Behcet, glomerulonefritis, púrpura trombocitopénica crónica, anemia hemolítica, hepatitis y granuloma de Wegner; y para tratar otras afecciones.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAM9gxQCHJ1dg0I8Q9S8PV3CfVxDPH0c1dw9vcN8A_1cwlWcPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8b4RRgYGlgaGBgZmBo7GRCkCAKuuJw8</recordid><startdate>20100120</startdate><enddate>20100120</enddate><creator>JIAN LIN</creator><creator>BRIAN ALAN LANMAN</creator><creator>KIMBERLEY GANNON</creator><creator>ZHAODA ZHANG</creator><creator>XIANG Y. YU</creator><creator>ASHIS SAHA</creator><creator>SRINIVASA R. CHERUKU</creator><creator>ROBERT C. PENLAND</creator><creator>PINI ORBACH</creator><creator>SHARON SHACHAM</creator><creator>OREN BECKER</creator><creator>SUSANA NEIRA</creator><creator>DILARA MCCAULEY</creator><creator>SILVIA NOIMAN</creator><creator>NILI SCHUTZ</creator><creator>ANURAG SHARADENDU</creator><creator>JENNIFER GOLDEN</creator><creator>MERCEDES LOBERA</creator><creator>VICTOR J. CEE</creator><creator>ROLAND BURLI</creator><scope>EVB</scope></search><sort><creationdate>20100120</creationdate><title>SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF</title><author>JIAN LIN ; BRIAN ALAN LANMAN ; KIMBERLEY GANNON ; ZHAODA ZHANG ; XIANG Y. YU ; ASHIS SAHA ; SRINIVASA R. CHERUKU ; ROBERT C. PENLAND ; PINI ORBACH ; SHARON SHACHAM ; OREN BECKER ; SUSANA NEIRA ; DILARA MCCAULEY ; SILVIA NOIMAN ; NILI SCHUTZ ; ANURAG SHARADENDU ; JENNIFER GOLDEN ; MERCEDES LOBERA ; VICTOR J. CEE ; ROLAND BURLI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2009010060A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JIAN LIN</creatorcontrib><creatorcontrib>BRIAN ALAN LANMAN</creatorcontrib><creatorcontrib>KIMBERLEY GANNON</creatorcontrib><creatorcontrib>ZHAODA ZHANG</creatorcontrib><creatorcontrib>XIANG Y. YU</creatorcontrib><creatorcontrib>ASHIS SAHA</creatorcontrib><creatorcontrib>SRINIVASA R. CHERUKU</creatorcontrib><creatorcontrib>ROBERT C. PENLAND</creatorcontrib><creatorcontrib>PINI ORBACH</creatorcontrib><creatorcontrib>SHARON SHACHAM</creatorcontrib><creatorcontrib>OREN BECKER</creatorcontrib><creatorcontrib>SUSANA NEIRA</creatorcontrib><creatorcontrib>DILARA MCCAULEY</creatorcontrib><creatorcontrib>SILVIA NOIMAN</creatorcontrib><creatorcontrib>NILI SCHUTZ</creatorcontrib><creatorcontrib>ANURAG SHARADENDU</creatorcontrib><creatorcontrib>JENNIFER GOLDEN</creatorcontrib><creatorcontrib>MERCEDES LOBERA</creatorcontrib><creatorcontrib>VICTOR J. CEE</creatorcontrib><creatorcontrib>ROLAND BURLI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIAN LIN</au><au>BRIAN ALAN LANMAN</au><au>KIMBERLEY GANNON</au><au>ZHAODA ZHANG</au><au>XIANG Y. YU</au><au>ASHIS SAHA</au><au>SRINIVASA R. CHERUKU</au><au>ROBERT C. PENLAND</au><au>PINI ORBACH</au><au>SHARON SHACHAM</au><au>OREN BECKER</au><au>SUSANA NEIRA</au><au>DILARA MCCAULEY</au><au>SILVIA NOIMAN</au><au>NILI SCHUTZ</au><au>ANURAG SHARADENDU</au><au>JENNIFER GOLDEN</au><au>MERCEDES LOBERA</au><au>VICTOR J. CEE</au><au>ROLAND BURLI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF</title><date>2010-01-20</date><risdate>2010</risdate><abstract>The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
La presente invención se refiere a compuestos de la fórmula general (I) que tienen actividad como agentes moduladores del receptor de S1P y al uso de estos compuestos para tratar enfermedades asociadas con actividad inadecuada del receptor de S1P. Los compuestos pueden usarse como inmunomoduladores, por ejemplo, para tratar o prevenir enfermedades tales como trastornos autoinmunes e inmunitarios relacionados incluyendo lupus eritematoso sistémico, enfermedades inflamatorias del intestino tales como enferedad de Crohn y colitis ulcerosa, diabetes tipo I, uveítis, psoriasis, maistenia grave, artritis reumatoide, nefrosis no glomerular, hepatitis, enfermedad de Behcet, glomerulonefritis, púrpura trombocitopénica crónica, anemia hemolítica, hepatitis y granuloma de Wegner; y para tratar otras afecciones.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; spa |
| recordid | cdi_epo_espacenet_MX2009010060A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | SIP RECEPTOR MODULATING COMPOUNDS AND USE THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T17%3A50%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JIAN%20LIN&rft.date=2010-01-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EMX2009010060A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |