PYRROLIDINE DERIVATIVE OR SALT THEREOF
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl...
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| creator | HANA MUKAI MAKOTO OKU RYUSHI SEO TAKASHI SHIN KOUSEI YOSHIHARA YOH TERADA TAISUKE TAKAHASHI MASANAO SANAGI KEISUKE MATSUURA SHUNICHIRO HACHIYA TAKASHI KAMIKUBO |
| description | [PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
[Problema] Para proporcionar un compuesto que puede utilizarse en el tratamiento de enfermedades en los cuales se relaciona el receptor sensibilizador del calcio (CaSR), particularmente hiperparatiroidismo. [Medios para la Resolucion] Se encontro que derivados de pirrolidina novedosos que se caracterizan por la posesion del grupo aminometilo sustituido con un grupo arilalquilo o similares, o sales de los mismos, tienen excelente actividad reguladora agonista de CaSR y tambien tienen excelente selectividad con la actividad inhibidora de CYP2D6 que tiene una posibilidad de causar interaccion de farmaco. Basado en lo anterior, estos derivados de pirrolidina novedosos son utiles como agentes terapeuticos para tratar enfermedades en los cuales se relaciona el CaSR (hiperparatiroidismo, osteodistrofia renal, hipercalcemia y similar). |
| format | Patent |
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[Problema] Para proporcionar un compuesto que puede utilizarse en el tratamiento de enfermedades en los cuales se relaciona el receptor sensibilizador del calcio (CaSR), particularmente hiperparatiroidismo. [Medios para la Resolucion] Se encontro que derivados de pirrolidina novedosos que se caracterizan por la posesion del grupo aminometilo sustituido con un grupo arilalquilo o similares, o sales de los mismos, tienen excelente actividad reguladora agonista de CaSR y tambien tienen excelente selectividad con la actividad inhibidora de CYP2D6 que tiene una posibilidad de causar interaccion de farmaco. Basado en lo anterior, estos derivados de pirrolidina novedosos son utiles como agentes terapeuticos para tratar enfermedades en los cuales se relaciona el CaSR (hiperparatiroidismo, osteodistrofia renal, hipercalcemia y similar).</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080211&DB=EPODOC&CC=MX&NR=2007014441A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080211&DB=EPODOC&CC=MX&NR=2007014441A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANA MUKAI</creatorcontrib><creatorcontrib>MAKOTO OKU</creatorcontrib><creatorcontrib>RYUSHI SEO</creatorcontrib><creatorcontrib>TAKASHI SHIN</creatorcontrib><creatorcontrib>KOUSEI YOSHIHARA</creatorcontrib><creatorcontrib>YOH TERADA</creatorcontrib><creatorcontrib>TAISUKE TAKAHASHI</creatorcontrib><creatorcontrib>MASANAO SANAGI</creatorcontrib><creatorcontrib>KEISUKE MATSUURA</creatorcontrib><creatorcontrib>SHUNICHIRO HACHIYA</creatorcontrib><creatorcontrib>TAKASHI KAMIKUBO</creatorcontrib><title>PYRROLIDINE DERIVATIVE OR SALT THEREOF</title><description>[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
[Problema] Para proporcionar un compuesto que puede utilizarse en el tratamiento de enfermedades en los cuales se relaciona el receptor sensibilizador del calcio (CaSR), particularmente hiperparatiroidismo. [Medios para la Resolucion] Se encontro que derivados de pirrolidina novedosos que se caracterizan por la posesion del grupo aminometilo sustituido con un grupo arilalquilo o similares, o sales de los mismos, tienen excelente actividad reguladora agonista de CaSR y tambien tienen excelente selectividad con la actividad inhibidora de CYP2D6 que tiene una posibilidad de causar interaccion de farmaco. Basado en lo anterior, estos derivados de pirrolidina novedosos son utiles como agentes terapeuticos para tratar enfermedades en los cuales se relaciona el CaSR (hiperparatiroidismo, osteodistrofia renal, hipercalcemia y similar).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALiAwK8vfxdPH0c1VwcQ3yDHMM8QxzVfAPUgh29AlRCPFwDXL1d-NhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfG-EUYGBuYGhiYmJoaOxkQpAgAfVyQr</recordid><startdate>20080211</startdate><enddate>20080211</enddate><creator>HANA MUKAI</creator><creator>MAKOTO OKU</creator><creator>RYUSHI SEO</creator><creator>TAKASHI SHIN</creator><creator>KOUSEI YOSHIHARA</creator><creator>YOH TERADA</creator><creator>TAISUKE TAKAHASHI</creator><creator>MASANAO SANAGI</creator><creator>KEISUKE MATSUURA</creator><creator>SHUNICHIRO HACHIYA</creator><creator>TAKASHI KAMIKUBO</creator><scope>EVB</scope></search><sort><creationdate>20080211</creationdate><title>PYRROLIDINE DERIVATIVE OR SALT THEREOF</title><author>HANA MUKAI ; MAKOTO OKU ; RYUSHI SEO ; TAKASHI SHIN ; KOUSEI YOSHIHARA ; YOH TERADA ; TAISUKE TAKAHASHI ; MASANAO SANAGI ; KEISUKE MATSUURA ; SHUNICHIRO HACHIYA ; TAKASHI KAMIKUBO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2007014441A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HANA MUKAI</creatorcontrib><creatorcontrib>MAKOTO OKU</creatorcontrib><creatorcontrib>RYUSHI SEO</creatorcontrib><creatorcontrib>TAKASHI SHIN</creatorcontrib><creatorcontrib>KOUSEI YOSHIHARA</creatorcontrib><creatorcontrib>YOH TERADA</creatorcontrib><creatorcontrib>TAISUKE TAKAHASHI</creatorcontrib><creatorcontrib>MASANAO SANAGI</creatorcontrib><creatorcontrib>KEISUKE MATSUURA</creatorcontrib><creatorcontrib>SHUNICHIRO HACHIYA</creatorcontrib><creatorcontrib>TAKASHI KAMIKUBO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANA MUKAI</au><au>MAKOTO OKU</au><au>RYUSHI SEO</au><au>TAKASHI SHIN</au><au>KOUSEI YOSHIHARA</au><au>YOH TERADA</au><au>TAISUKE TAKAHASHI</au><au>MASANAO SANAGI</au><au>KEISUKE MATSUURA</au><au>SHUNICHIRO HACHIYA</au><au>TAKASHI KAMIKUBO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRROLIDINE DERIVATIVE OR SALT THEREOF</title><date>2008-02-11</date><risdate>2008</risdate><abstract>[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
[Problema] Para proporcionar un compuesto que puede utilizarse en el tratamiento de enfermedades en los cuales se relaciona el receptor sensibilizador del calcio (CaSR), particularmente hiperparatiroidismo. [Medios para la Resolucion] Se encontro que derivados de pirrolidina novedosos que se caracterizan por la posesion del grupo aminometilo sustituido con un grupo arilalquilo o similares, o sales de los mismos, tienen excelente actividad reguladora agonista de CaSR y tambien tienen excelente selectividad con la actividad inhibidora de CYP2D6 que tiene una posibilidad de causar interaccion de farmaco. Basado en lo anterior, estos derivados de pirrolidina novedosos son utiles como agentes terapeuticos para tratar enfermedades en los cuales se relaciona el CaSR (hiperparatiroidismo, osteodistrofia renal, hipercalcemia y similar).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRROLIDINE DERIVATIVE OR SALT THEREOF |
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