INDOLE-2-CARBOXAMIDES AS FACTOR XA INHIBITORS

Ovaj pronalazak se odnosi na jedinjenja formule I gdje R0,R1,R2,R3,R4,R5,R6,R7,Q,V,G i M imaju značenja naznačena u patentnim zahtjevima. Jedinjenja formule (I) su vrijedna farmakološki aktivna jedinjenja. Ona ispoljavaju jak antitrombotski efekat i pogodna su za, na primjer, terapiju i profilaksu kardiovaskularnih poremećaja, kao što su tromboembolijske bolesti ili restonoza. To su reversibilni inhibitori faktora Xa i/ili faktora VIIa enzima za zgrušavanje krvi,a obično se mogu primijeniti u stanjima u kojima je prisutna nepoželjna aktivnost faktora Xa i/ili faktora VIIa, ili za liječenje ili prevenciju u kojima se zahtjeva inhibicija faktora Xa i/ili faktora VIIa. Ovaj pronalazak se još odnosi na postupke za dobijanje jedinjenja formule I, na njihovu upotrebu, a naročito kao aktivnih sastojaka u medikamentima ili farmaceutskim preparatima koji ih sadrže. The present invention relates to compounds of the formula I, in which R ; R ; R ; R ; R ; R ; R ; R ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them