CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS

Obezbeđena su karbonilaminopirolopirazol jedinjenja formule (1), preparati koji sadrže ova jedinjenja i postupci za njihovu upotrebu. Poželjna jedinjenja formule (l) poseduju aktivnost kao inhibitori protein kinaza, uključujući kao ihibitori PAK4. Carbonylamino Pyrrolopyrazole compounds of formula I...

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Bibliographische Detailangaben
Hauptverfasser:	MCALPINE, Indrawan James, LI, Haitao, GUO, Chuangxing, ZHANG, Junhu, DONG, Liming, YANG, Anle, KEPHART, Susan Elizabeth, JOHNSON, Mary Catherine, HONG, Yufeng, TIKHE, Jayashree Girish
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Obezbeđena su karbonilaminopirolopirazol jedinjenja formule (1), preparati koji sadrže ova jedinjenja i postupci za njihovu upotrebu. Poželjna jedinjenja formule (l) poseduju aktivnost kao inhibitori protein kinaza, uključujući kao ihibitori PAK4. Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.