Crystalline forms of an antiviral compound

The invention relates to crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I).(Compound I)Also provided are processes o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DASHNER Kathleen, SEO Mun Sik, CASTEEL Melissa Jean, ZIA Vahid, WANG Fang, JUNG Hyuk-jun, SHI Bing
Format:	Patent
Sprache:	eng ; rum ; rus
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I).(Compound I)Also provided are processes of making and methods of using the crystalline forms. Invenţia se referă la forme solide cristaline ale compusului anti-VHC (S)-izopropil 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2H)-il)-4-fluoro-3-hidroxi-4- metiltetrahidrofuran -2- il)metoxi)(fenoxi)fosforilamino)propanoat (Compusul I).(Compusul I)De asemenea, sunt descrise procedee de obţinere şi metode de utilizare a formelor cristaline. Изобретение относится к кристаллическим твердым формам соединения анти-HCV (S)-изопропил 2-((S)-(((2R,3R,4R,5R)-5-(2,4-диоксо-3,4-дигидропиримидин-1(2H)-ил)-4-фтор-3-гидрокси-4-метилтетрагидрофуран-2-ил)метокси)(фенокси) фосфориламино) пропаноат (Соединение I).(Соединение I)Также раскрыты способы получения и методы применения кристаллических форм.