Indole and indazole compounds that activate AMPK

The invention relates to indole and indazole compounds of Formula (I):that activate 5´ adenosine monophosphate-activated kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions or disorders ameli...

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Hauptverfasser:	BHATTACHARYA Samit Kumar, DOWLING Matthew Scott, KUNG Daniel Wei-Shung, CAMERON Kimberly O'Keefe, FERNANDO Dilinie Prasadhini, SMITH Aaron Christopher, EBNER David Christopher, FILIPSKI Kevin James, TU Meihua Mike, LEE Esther Cheng Yin
Format:	Patent
Sprache:	eng ; rum ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to indole and indazole compounds of Formula (I):that activate 5´ adenosine monophosphate-activated kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions or disorders ameliorated by activation of AMPK. Invenţia se referă la compuşi ai indolului şi indazolului cu formula (I):care activează protein-kinaza stimulată de 5' adenozin monofosfat (AMPK). Invenţia se mai referă la compoziţii farmaceutice care conţin aceşti compuşi şi la metode de tratare sau prevenire a bolilor, stărilor sau tulburărilor, intensitatea simptomelor cărora scade prin activarea AMPK. Изобретение относится к соединениям индола и индазола формулы (I):активирующим 5'-аденозин-монофосфат-активируемую протеинкиназу (AMPK). Изобретение также относится к фармацевтическим композициям, содержащим эти соединения, и к методам лечения или предупреждения заболеваний, состояний или расстройств, интенсивность симптомов которых уменьшается посредством активации AMPK.