Process for obtaining asymmetrical N,N'-malonyl-bis-diamides

Inventia se refera la un procedeu de obtinere a compusilor farmacologic activi, utilizati in practica medicala pentru tratamentul maladiilor cardio-vasculare. Procedeul de obtinere a N,N(-malonil-bis-diamidelor asimetrice include condensarea amino-componentului prim cu ester malonic in raport molar...

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Bibliographische Detailangaben
Hauptverfasser:	SHEPELI DIANA, MAKAEV FLYUR, SHEPELI FELIX
Format:	Patent
Sprache:	eng ; rum
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Inventia se refera la un procedeu de obtinere a compusilor farmacologic activi, utilizati in practica medicala pentru tratamentul maladiilor cardio-vasculare. Procedeul de obtinere a N,N(-malonil-bis-diamidelor asimetrice include condensarea amino-componentului prim cu ester malonic in raport molar de 1:5, in solvent inert la temperatura de 100...140°C, urmata de condensarea amino-componentului secund cu monoamida esterului malonic, obtinuta in stadiul anterior. ŕ