HYDROXAMIDES D'ACIDES 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRANNE-3-CARBOXYLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

L'INVENTION CONCERNE DES COMPOSÉS DE FORMULE :DANS LAQUELLE R1, R2, R3, R4 ET Q REPRÉSENTENT DIVERS RADICAUX. ELLE CONCERNE ÉGALEMENT UN PROCÉDÉ POUR LEUR PRÉPARATION ET DES COMPOSITIONS PHARMACUTIQUES LES CONTENANT. - APPLICATION : UTILISATION DE CES COMPOSÉS ET COMPOSITIONS, COMME INHIBITEURS...

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1. Verfasser: LAWRENCE ALAN REITER
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description L'INVENTION CONCERNE DES COMPOSÉS DE FORMULE :DANS LAQUELLE R1, R2, R3, R4 ET Q REPRÉSENTENT DIVERS RADICAUX. ELLE CONCERNE ÉGALEMENT UN PROCÉDÉ POUR LEUR PRÉPARATION ET DES COMPOSITIONS PHARMACUTIQUES LES CONTENANT. - APPLICATION : UTILISATION DE CES COMPOSÉS ET COMPOSITIONS, COMME INHIBITEURS D'ENZYMES, POUR LE TRAITEMENT DE DIVERSES MALADIES. A compound of the formulawherein R1, R2, R3, R4 and Q are as defined above, are useful in the treatment of arthritis (including osteoarthritis and rheumatoid arthritis), cancer and other diseases. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HYDROXAMIDES D'ACIDES 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRANNE-3-CARBOXYLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
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