METHOD FOR PRODUCTION OF LENALIDOMIDE
Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-...
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| creator | EBEDEVS ANTONS PONOMARJOVS JURIJS KALVI Š IVARS ERNOBROVIJS ALEKSANDRS VARA EVA LARISA |
| description | Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione using reduction-system of iron and ammonium chloride.
Aprakstīti uzlabojumi 3-(4-amino-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona (lenalidomīda) iegūšanas procesā, starpproduktu 2-metil-3-nitrobenzoskābes metilesteri bromējot metilacetātā ar N-bromsukcīnimīdu, un galaproduktu iegūstot no 3-(4-nitro-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona, pēdējo reducējot ar dzelzs un amonija hlorīda reducējošo sistēmu. |
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Aprakstīti uzlabojumi 3-(4-amino-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona (lenalidomīda) iegūšanas procesā, starpproduktu 2-metil-3-nitrobenzoskābes metilesteri bromējot metilacetātā ar N-bromsukcīnimīdu, un galaproduktu iegūstot no 3-(4-nitro-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona, pēdējo reducējot ar dzelzs un amonija hlorīda reducējošo sistēmu.]]></description><language>eng ; lav</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150420&DB=EPODOC&CC=LV&NR=14985A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150420&DB=EPODOC&CC=LV&NR=14985A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EBEDEVS ANTONS</creatorcontrib><creatorcontrib>PONOMARJOVS JURIJS</creatorcontrib><creatorcontrib>KALVI Š IVARS</creatorcontrib><creatorcontrib>ERNOBROVIJS ALEKSANDRS</creatorcontrib><creatorcontrib>VARA EVA LARISA</creatorcontrib><title>METHOD FOR PRODUCTION OF LENALIDOMIDE</title><description><![CDATA[Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione using reduction-system of iron and ammonium chloride.
Aprakstīti uzlabojumi 3-(4-amino-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona (lenalidomīda) iegūšanas procesā, starpproduktu 2-metil-3-nitrobenzoskābes metilesteri bromējot metilacetātā ar N-bromsukcīnimīdu, un galaproduktu iegūstot no 3-(4-nitro-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona, pēdējo reducējot ar dzelzs un amonija hlorīda reducējošo sistēmu.]]></description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD1dQ3x8HdRcPMPUggI8ncJdQ7x9PdT8HdT8HH1c_TxdPH39XRx5WFgTUvMKU7lhdLcDLJuriHOHrqpBfnxqcUFicmpeakl8T5hhiaWFqaOxoTkAZadIcc</recordid><startdate>20150420</startdate><enddate>20150420</enddate><creator>EBEDEVS ANTONS</creator><creator>PONOMARJOVS JURIJS</creator><creator>KALVI Š IVARS</creator><creator>ERNOBROVIJS ALEKSANDRS</creator><creator>VARA EVA LARISA</creator><scope>EVB</scope></search><sort><creationdate>20150420</creationdate><title>METHOD FOR PRODUCTION OF LENALIDOMIDE</title><author>EBEDEVS ANTONS ; PONOMARJOVS JURIJS ; KALVI Š IVARS ; ERNOBROVIJS ALEKSANDRS ; VARA EVA LARISA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_LV14985A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; lav</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>EBEDEVS ANTONS</creatorcontrib><creatorcontrib>PONOMARJOVS JURIJS</creatorcontrib><creatorcontrib>KALVI Š IVARS</creatorcontrib><creatorcontrib>ERNOBROVIJS ALEKSANDRS</creatorcontrib><creatorcontrib>VARA EVA LARISA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>EBEDEVS ANTONS</au><au>PONOMARJOVS JURIJS</au><au>KALVI Š IVARS</au><au>ERNOBROVIJS ALEKSANDRS</au><au>VARA EVA LARISA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PRODUCTION OF LENALIDOMIDE</title><date>2015-04-20</date><risdate>2015</risdate><abstract><![CDATA[Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione using reduction-system of iron and ammonium chloride.
Aprakstīti uzlabojumi 3-(4-amino-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona (lenalidomīda) iegūšanas procesā, starpproduktu 2-metil-3-nitrobenzoskābes metilesteri bromējot metilacetātā ar N-bromsukcīnimīdu, un galaproduktu iegūstot no 3-(4-nitro-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona, pēdējo reducējot ar dzelzs un amonija hlorīda reducējošo sistēmu.]]></abstract><oa>free_for_read</oa></addata></record> |
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| title | METHOD FOR PRODUCTION OF LENALIDOMIDE |
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