METHOD FOR PRODUCTION OF LENALIDOMIDE

METHOD FOR PRODUCTION OF LENALIDOMIDE

Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: EBEDEVS ANTONS, PONOMARJOVS JURIJS, KALVI Š IVARS, ERNOBROVIJS ALEKSANDRS, VARA EVA LARISA
Format: Patent
Sprache:eng ; lav
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Improvements for production of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione (lenalidomide) are disclosed, that include bromination of methyl 2-methyl-3-nitro-benzoate with N-bromosuccinimide in methyl acetate solution and obtaining end-product by reduction of 3-(4-nitro-1-oxo-1,3-dihydro-2H-isoindole-2-yl)piperidine-2,6-dione using reduction-system of iron and ammonium chloride. Aprakstīti uzlabojumi 3-(4-amino-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona (lenalidomīda) iegūšanas procesā, starpproduktu 2-metil-3-nitrobenzoskābes metilesteri bromējot metilacetātā ar N-bromsukcīnimīdu, un galaproduktu iegūstot no 3-(4-nitro-1-okso-1,3-dihidro-2H-izoindol-2-il)piperidīn-2,6-diona, pēdējo reducējot ar dzelzs un amonija hlorīda reducējošo sistēmu.