POTASSIUM SALTS OF N-PROPIONYL-4-HYDROXY-3-NITRO-L-PHENYLALANINE AND N-PROPIONYL-4-METOXY-3-NITRO-DL-PHENYLALANINE HAVING ANTITUMOUR ACTIVITY

POTASSIUM SALTS OF N-PROPIONYL-4-HYDROXY-3-NITRO-L-PHENYLALANINE AND N-PROPIONYL-4-METOXY-3-NITRO-DL-PHENYLALANINE HAVING ANTITUMOUR ACTIVITY

This invention describes biologically active compounds, such as water-soluble N-propionil-4-hydroxy-3-nitro-L-phenylalanine and N-propionyl-4-methoxy-3-nitro-DL-phenylalanine potassium salts. The synthetic derivatives of amino acids are slightly toxic, but the experiments with mice have shown a high...

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Bibliographische Detailangaben
Hauptverfasser: SIMKEVICIENE,VITALIJA, STRAUKAS,JUOZAPAS, JANKAUSKAS,RIMAS
Format: Patent
Sprache:eng ; lit
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:This invention describes biologically active compounds, such as water-soluble N-propionil-4-hydroxy-3-nitro-L-phenylalanine and N-propionyl-4-methoxy-3-nitro-DL-phenylalanine potassium salts. The synthetic derivatives of amino acids are slightly toxic, but the experiments with mice have shown a high level of effect against cells affected by cancer. They slow down the growth of sarcoma 180, respectively by 94.5 and 89 per cent, and lengthen the time of living by up to 50 per cent.