SUBSTITUTED TRICYCLIC COMPOUNDS
Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferativ...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; lit |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | PHUKAN, Samiron SINDKHEDKAR, Milind PALLE, Venkata NAIR, Prathap WAGH, Pradip KAMBOJ, Rajender DUBE, Dagadu KHEDKAR, Nilesh SETHI, Sachin BALGUDE, Sudhakar PATIL, Pradeep TAMBE, Vikas SHUKLA, Manojkumar KAKADE, Ganesh |
| description | Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_LT4065575TT</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>LT4065575TT</sourcerecordid><originalsourceid>FETCH-epo_espacenet_LT4065575TT3</originalsourceid><addsrcrecordid>eNrjZJAPDnUKDvEMCQ1xdVEICfJ0jnT28XRWcPb3DfAP9XMJ5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8T4hJgZmpqbmpiEhxkQoAQDLACIu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED TRICYCLIC COMPOUNDS</title><source>esp@cenet</source><creator>PHUKAN, Samiron ; SINDKHEDKAR, Milind ; PALLE, Venkata ; NAIR, Prathap ; WAGH, Pradip ; KAMBOJ, Rajender ; DUBE, Dagadu ; KHEDKAR, Nilesh ; SETHI, Sachin ; BALGUDE, Sudhakar ; PATIL, Pradeep ; TAMBE, Vikas ; SHUKLA, Manojkumar ; KAKADE, Ganesh</creator><creatorcontrib>PHUKAN, Samiron ; SINDKHEDKAR, Milind ; PALLE, Venkata ; NAIR, Prathap ; WAGH, Pradip ; KAMBOJ, Rajender ; DUBE, Dagadu ; KHEDKAR, Nilesh ; SETHI, Sachin ; BALGUDE, Sudhakar ; PATIL, Pradeep ; TAMBE, Vikas ; SHUKLA, Manojkumar ; KAKADE, Ganesh</creatorcontrib><description>Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.</description><language>eng ; lit</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240527&DB=EPODOC&CC=LT&NR=4065575T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240527&DB=EPODOC&CC=LT&NR=4065575T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PHUKAN, Samiron</creatorcontrib><creatorcontrib>SINDKHEDKAR, Milind</creatorcontrib><creatorcontrib>PALLE, Venkata</creatorcontrib><creatorcontrib>NAIR, Prathap</creatorcontrib><creatorcontrib>WAGH, Pradip</creatorcontrib><creatorcontrib>KAMBOJ, Rajender</creatorcontrib><creatorcontrib>DUBE, Dagadu</creatorcontrib><creatorcontrib>KHEDKAR, Nilesh</creatorcontrib><creatorcontrib>SETHI, Sachin</creatorcontrib><creatorcontrib>BALGUDE, Sudhakar</creatorcontrib><creatorcontrib>PATIL, Pradeep</creatorcontrib><creatorcontrib>TAMBE, Vikas</creatorcontrib><creatorcontrib>SHUKLA, Manojkumar</creatorcontrib><creatorcontrib>KAKADE, Ganesh</creatorcontrib><title>SUBSTITUTED TRICYCLIC COMPOUNDS</title><description>Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAPDnUKDvEMCQ1xdVEICfJ0jnT28XRWcPb3DfAP9XMJ5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8T4hJgZmpqbmpiEhxkQoAQDLACIu</recordid><startdate>20240527</startdate><enddate>20240527</enddate><creator>PHUKAN, Samiron</creator><creator>SINDKHEDKAR, Milind</creator><creator>PALLE, Venkata</creator><creator>NAIR, Prathap</creator><creator>WAGH, Pradip</creator><creator>KAMBOJ, Rajender</creator><creator>DUBE, Dagadu</creator><creator>KHEDKAR, Nilesh</creator><creator>SETHI, Sachin</creator><creator>BALGUDE, Sudhakar</creator><creator>PATIL, Pradeep</creator><creator>TAMBE, Vikas</creator><creator>SHUKLA, Manojkumar</creator><creator>KAKADE, Ganesh</creator><scope>EVB</scope></search><sort><creationdate>20240527</creationdate><title>SUBSTITUTED TRICYCLIC COMPOUNDS</title><author>PHUKAN, Samiron ; SINDKHEDKAR, Milind ; PALLE, Venkata ; NAIR, Prathap ; WAGH, Pradip ; KAMBOJ, Rajender ; DUBE, Dagadu ; KHEDKAR, Nilesh ; SETHI, Sachin ; BALGUDE, Sudhakar ; PATIL, Pradeep ; TAMBE, Vikas ; SHUKLA, Manojkumar ; KAKADE, Ganesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_LT4065575TT3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; lit</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PHUKAN, Samiron</creatorcontrib><creatorcontrib>SINDKHEDKAR, Milind</creatorcontrib><creatorcontrib>PALLE, Venkata</creatorcontrib><creatorcontrib>NAIR, Prathap</creatorcontrib><creatorcontrib>WAGH, Pradip</creatorcontrib><creatorcontrib>KAMBOJ, Rajender</creatorcontrib><creatorcontrib>DUBE, Dagadu</creatorcontrib><creatorcontrib>KHEDKAR, Nilesh</creatorcontrib><creatorcontrib>SETHI, Sachin</creatorcontrib><creatorcontrib>BALGUDE, Sudhakar</creatorcontrib><creatorcontrib>PATIL, Pradeep</creatorcontrib><creatorcontrib>TAMBE, Vikas</creatorcontrib><creatorcontrib>SHUKLA, Manojkumar</creatorcontrib><creatorcontrib>KAKADE, Ganesh</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PHUKAN, Samiron</au><au>SINDKHEDKAR, Milind</au><au>PALLE, Venkata</au><au>NAIR, Prathap</au><au>WAGH, Pradip</au><au>KAMBOJ, Rajender</au><au>DUBE, Dagadu</au><au>KHEDKAR, Nilesh</au><au>SETHI, Sachin</au><au>BALGUDE, Sudhakar</au><au>PATIL, Pradeep</au><au>TAMBE, Vikas</au><au>SHUKLA, Manojkumar</au><au>KAKADE, Ganesh</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED TRICYCLIC COMPOUNDS</title><date>2024-05-27</date><risdate>2024</risdate><abstract>Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; lit |
| recordid | cdi_epo_espacenet_LT4065575TT |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED TRICYCLIC COMPOUNDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T19%3A14%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PHUKAN,%20Samiron&rft.date=2024-05-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ELT4065575TT%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |