PHENYLDIFLUOROMETHYL-SUBSTITUTED PROLINAMIDE COMPOUND

[Problem]To provide a compound useful as a cathepsin S inhibitor.[Means for Solution]The present inventors have examined a compound that has a cathepsin S inhibitory effect and is usable as an active ingredient of a pharmaceutical composition for preventing and/or treating autoimmune disease includi...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUMOTO, Shunichiro, NAKAJIMA, Yutaka, HARAYAMA, Yu, IMADA, Sunao, TSUCHIYA, Kazuyuki, YAMAMOTO, Eriko
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	[Problem]To provide a compound useful as a cathepsin S inhibitor.[Means for Solution]The present inventors have examined a compound that has a cathepsin S inhibitory effect and is usable as an active ingredient of a pharmaceutical composition for preventing and/or treating autoimmune disease including systemic lupus erythematosus (SLE) and lupus nephritis, allergies, or graft rejection of an organ, bone marrow or tissue, and have found that a phenyldifluoromethyl-substituted prolinamide compound of the present invention has the cathepsin S inhibitory effect, thereby completing the present invention. The phenyldifluoromethyl-substituted prolinamide compound of the present invention has the cathepsin S inhibitory effect and is useful as an agent for preventing and/or treating autoimmune disease including SLE and nephritis, allergies, or graft rejection of an organ, bone marrow or tissue.