SUBSTITUTED CHROMANES AND METHOD OF USE
wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibr...
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| creator | WANG, Xueqing KYM, Philip R YEUNG, Ming C VOIGHT, Eric BOGDAN, Andrew SEARLE, Xenia B LIU, Bo ALTENBACH, Robert J KOENIG, John R GRESZLER, Stephen N |
| description | wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I). |
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Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).</description><language>eng ; lit</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201125&DB=EPODOC&CC=LT&NR=3212189T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201125&DB=EPODOC&CC=LT&NR=3212189T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG, Xueqing</creatorcontrib><creatorcontrib>KYM, Philip R</creatorcontrib><creatorcontrib>YEUNG, Ming C</creatorcontrib><creatorcontrib>VOIGHT, Eric</creatorcontrib><creatorcontrib>BOGDAN, Andrew</creatorcontrib><creatorcontrib>SEARLE, Xenia B</creatorcontrib><creatorcontrib>LIU, Bo</creatorcontrib><creatorcontrib>ALTENBACH, Robert J</creatorcontrib><creatorcontrib>KOENIG, John R</creatorcontrib><creatorcontrib>GRESZLER, Stephen N</creatorcontrib><title>SUBSTITUTED CHROMANES AND METHOD OF USE</title><description>wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. 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Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED CHROMANES AND METHOD OF USE |
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