Granules for pharmaceutical preparations, methods and apparatus for their production

Granules for pharmaceutical preparations, methods and apparatus for their production

Disclosed are improved granular pharmaceutical preparations, together with improved methods and apparatus for preparation of granules for use in such preparations. Such methods are especially useful for making granules for solid oral dose pharmaceutical preparations, and are particularly suited to t...

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Hauptverfasser: HOEG-MOLLER, Carsten, PEDERSEN, Kenneth Manby, HANSEN, Tue, POULSEN, Helle, NISSEN, Brigitte, WITTENDORFF, Jorgen, LARSEN, Crilles Casper
Format: Patent
Sprache:eng ; lit
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator HOEG-MOLLER, Carsten
PEDERSEN, Kenneth Manby
HANSEN, Tue
POULSEN, Helle
NISSEN, Brigitte
WITTENDORFF, Jorgen
LARSEN, Crilles Casper
description Disclosed are improved granular pharmaceutical preparations, together with improved methods and apparatus for preparation of granules for use in such preparations. Such methods are especially useful for making granules for solid oral dose pharmaceutical preparations, and are particularly suited to the production of granules comprising 5-aminosalicylic acid (5-ASA) for the treatment of inflammatory bowel disease. The granules exhibit a more sharply peaked length distribution, and hence aspect ratio distribution, and have a consequently much sharper dissolution profile after further processing.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Granules for pharmaceutical preparations, methods and apparatus for their production
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