HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES

Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. the heterocyclic aromatic compounds have structure (I) incl...

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Bibliographische Detailangaben
Hauptverfasser:	SWARTZ,STEPHEN G, ROBL,JEFFREY, LI,JAMES J, TINO,JOSEPH A, LI,JUN, HERNANDEZ,ANDRES S
Format:	Patent
Sprache:	eng ; lit
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. the heterocyclic aromatic compounds have structure (I) including pharmaceutically acceptable salts thereof and all stereoisomers thereof, wherein Xa is heteroaryl, preferably (a), (b) or (c) and R1, R1a, R6, Y, Xb, A, B, Z, R3, R4, R4a, R5 and R5a are as defined herein. Išradime pateikti heterocikliniai aromatiniai junginiai, kurie tinka augimo hormono endogeninei produkcijai arba išsiskyrimui stimuliuoti ir nutukimui, osteoporozei (gerina kaulų tankį) gydyti bei reumens masei ir raumens jėgai padidinti. Šie heterocikliniai aromatiniai junginiai turi struktūrą (I), įskaitant jų farmaciškai priimtinas druskas ir visus jų izomerus, kuriuose Xa yra heteroarilas, geriausia (a), (b) arba (c), o R1, R1a, R6, Y, Xb, A, B, Z, R3, R4, R4a, R5 ir R5a turi aprašyme nurodytas reikšmes.ą