HIRUDIN DERIVATIVE

A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.

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Bibliographische Detailangaben
Hauptverfasser: TRIPIER, DOMINIQUE, CRAUSE, PETER, HABERMANN, PAUL
Format: Patent
Sprache:eng
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Zusammenfassung:A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.