PROCESS FOR PREPARING ERGOLENENE DERIVATIVES

The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) (I) wherein X stands for a halogen; R stands for a C1-4...

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Bibliographische Detailangaben
Hauptverfasser:	KISS, BELA, MEGYERI, GABOR, SEPORNY, LASZLO, LASZLOVSZKY, ISTVAN, LAPIS, ERZSEBET, GROO, DORA, TUN, K. LAJOS, PALOSI, EVA, STEFKO, BELA, TIBOR, KEVE, ZIEGER, K. ANNA
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) (I) wherein X stands for a halogen; R stands for a C1-4 alkyl group and R'' means a hydroxyl group; or R stands for an acyl or substituted acyl group and R'' represents a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; or R stands for hydrogen and R'' means a halogen or an -OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions. The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect.