DOXORUBICIN HYDROCHLORIDE NONAQUEOUS SOLUTION

DOXORUBICIN HYDROCHLORIDE NONAQUEOUS SOLUTION

Stable, concentrated, non-aqueous solutions of doxorubicin HCl are provided containing doxorubicin HCl, citric acid and an antioxidant selected from sodium formaldehyde bisulfite, tert-butylhydroquinone and alpha -tocopherol (Vitamin E) in a solvent medium consisting of propylene glycol, 1,2-dihydro...

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Hauptverfasser: PERRONE, ROBERT K, KAPLAN, MURRAY A, BOGARDUS, JOSEPH B
Format: Patent
Sprache:eng ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator PERRONE, ROBERT K
KAPLAN, MURRAY A
BOGARDUS, JOSEPH B
description Stable, concentrated, non-aqueous solutions of doxorubicin HCl are provided containing doxorubicin HCl, citric acid and an antioxidant selected from sodium formaldehyde bisulfite, tert-butylhydroquinone and alpha -tocopherol (Vitamin E) in a solvent medium consisting of propylene glycol, 1,2-dihydroxybutane or 1,3-dihydroxypropane, or mixtures of such non-aqueous solvents with water. The solutions have an acceptable shelf-life of greater than 18 months at room temperature and can be diluted with water or other aqueous parenteral vehicles for parenteral administration.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DOXORUBICIN HYDROCHLORIDE NONAQUEOUS SOLUTION
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