PROCESS FOR PREPARING 1-(ACYLAMINO-ARYLOXY)-2-HYDROXY-3-ALKINYL-AMINOPROPANES

PROCESS FOR PREPARING 1-(ACYLAMINO-ARYLOXY)-2-HYDROXY-3-ALKINYL-AMINOPROPANES

Compds. I [R1 = C4-7 n - or branched-alkyl; R2 = H; R3 = H, C1-3 alkyl; R4 = C1-3 alkyl; or R3R4 = (CH2)n n = 4-6 were prepd. as, e.g., antiarrhythmics. Thus, 14g 1-(2-cyano-4- - methylpentanoylaminophenoxy)-2,3-epoxypropane was refluxed for 1hr. with 12.5g 2-methylbutyne-3-amine-2 in 100mL EtOH to...

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Hauptverfasser: TRAUNECKER, WERNER, STAHLE, HELMUT, KUMMER, WERNER, MUACEVIC, GOJKO, KOPPE, HERBERT
Format: Patent
Sprache:eng ; kor
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator TRAUNECKER, WERNER
STAHLE, HELMUT
KUMMER, WERNER
MUACEVIC, GOJKO
KOPPE, HERBERT
description Compds. I [R1 = C4-7 n - or branched-alkyl; R2 = H; R3 = H, C1-3 alkyl; R4 = C1-3 alkyl; or R3R4 = (CH2)n n = 4-6 were prepd. as, e.g., antiarrhythmics. Thus, 14g 1-(2-cyano-4- - methylpentanoylaminophenoxy)-2,3-epoxypropane was refluxed for 1hr. with 12.5g 2-methylbutyne-3-amine-2 in 100mL EtOH to give 7.4 g 1-(2- cyano-4- -methylpentanoylamino-phenoxy)-3-(2-methylbutynyl3-amino-2)- 2-propane.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR PREPARING 1-(ACYLAMINO-ARYLOXY)-2-HYDROXY-3-ALKINYL-AMINOPROPANES
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