PROCESS FOR PREPARING NICOTINAMIDE DERIVATIVES

PROCESS FOR PREPARING NICOTINAMIDE DERIVATIVES

Title compd. (I) was prepd. by reaction of nicotinic acid and 1,2-diaminopropane. Thus, 4.7g 1,2-diaminopropane was reacted with 25g nicotinoyl chloride-HCI in 200ml pyridine and 50ml triethylamine for 1hr, and extracted with tetrahydrofuran, to give 1,2-bis(nicotinamido) propane. I was effective in...

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Hauptverfasser: MORI TAKASHI, MATSUURA FUMIAKI, YAMOZAKI TAMOTSU, TAKAKU SAKAE, NODA YUKIFUMI, MURAKAMI YASUSHI
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title compd. (I) was prepd. by reaction of nicotinic acid and 1,2-diaminopropane. Thus, 4.7g 1,2-diaminopropane was reacted with 25g nicotinoyl chloride-HCI in 200ml pyridine and 50ml triethylamine for 1hr, and extracted with tetrahydrofuran, to give 1,2-bis(nicotinamido) propane. I was effective in treating spasms in cerebral blood vessels and in the prevention of atherosclerosis and thrombosis.