PROCESS FOR THE PREPARATION OF 3,7,11,15-TETRAMETHYL-2,4,6,10,14-HEXADECA PENTAENOIC ACID
Title compds.I, used as anticancer, were prepd. by the hydrolysis of TV(R=C1-4 alkyl) in the precense of base. And TV were prepd. from III(X=halogen atom; n=0-1) with witting reagent. Thus, 28.6g triethyl phosphonoacetate was added to the suspension of 5g 55% NaOH in n-hexane. 20g 6,10,14-trimethyl-...
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| creator | INAI YUICHI YAMATSU ISAO ABE KOUICHI SUZUKI KOUICHI YAMADA KOUJI TAGAYA OSAMU |
| description | Title compds.I, used as anticancer, were prepd. by the hydrolysis of TV(R=C1-4 alkyl) in the precense of base. And TV were prepd. from III(X=halogen atom; n=0-1) with witting reagent. Thus, 28.6g triethyl phosphonoacetate was added to the suspension of 5g 55% NaOH in n-hexane. 20g 6,10,14-trimethyl-3,5,9,13-pentadecatetraen-2-on was added under reflux. Extracted with n-hexane and purified with column chromatography. 3.9g NaOH in isopropylalcohol was added and stirred at 50oC. Extracted with ether. Obtained oil was crystalized in n-hexane and 4.0g 3,7,11,15-tetramethyl-2,4,6,10,14-hexa-decapentaenoic acid was obtained.(mp. 78.4oC) |
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And TV were prepd. from III(X=halogen atom; n=0-1) with witting reagent. Thus, 28.6g triethyl phosphonoacetate was added to the suspension of 5g 55% NaOH in n-hexane. 20g 6,10,14-trimethyl-3,5,9,13-pentadecatetraen-2-on was added under reflux. Extracted with n-hexane and purified with column chromatography. 3.9g NaOH in isopropylalcohol was added and stirred at 50oC. Extracted with ether. Obtained oil was crystalized in n-hexane and 4.0g 3,7,11,15-tetramethyl-2,4,6,10,14-hexa-decapentaenoic acid was obtained.(mp. 78.4oC)</description><language>eng ; kor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840929&DB=EPODOC&CC=KR&NR=840001518B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840929&DB=EPODOC&CC=KR&NR=840001518B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>INAI YUICHI</creatorcontrib><creatorcontrib>YAMATSU ISAO</creatorcontrib><creatorcontrib>ABE KOUICHI</creatorcontrib><creatorcontrib>SUZUKI KOUICHI</creatorcontrib><creatorcontrib>YAMADA KOUJI</creatorcontrib><creatorcontrib>TAGAYA OSAMU</creatorcontrib><title>PROCESS FOR THE PREPARATION OF 3,7,11,15-TETRAMETHYL-2,4,6,10,14-HEXADECA PENTAENOIC ACID</title><description>Title compds.I, used as anticancer, were prepd. by the hydrolysis of TV(R=C1-4 alkyl) in the precense of base. And TV were prepd. from III(X=halogen atom; n=0-1) with witting reagent. Thus, 28.6g triethyl phosphonoacetate was added to the suspension of 5g 55% NaOH in n-hexane. 20g 6,10,14-trimethyl-3,5,9,13-pentadecatetraen-2-on was added under reflux. Extracted with n-hexane and purified with column chromatography. 3.9g NaOH in isopropylalcohol was added and stirred at 50oC. Extracted with ether. 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And TV were prepd. from III(X=halogen atom; n=0-1) with witting reagent. Thus, 28.6g triethyl phosphonoacetate was added to the suspension of 5g 55% NaOH in n-hexane. 20g 6,10,14-trimethyl-3,5,9,13-pentadecatetraen-2-on was added under reflux. Extracted with n-hexane and purified with column chromatography. 3.9g NaOH in isopropylalcohol was added and stirred at 50oC. Extracted with ether. Obtained oil was crystalized in n-hexane and 4.0g 3,7,11,15-tetramethyl-2,4,6,10,14-hexa-decapentaenoic acid was obtained.(mp. 78.4oC)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS |
| title | PROCESS FOR THE PREPARATION OF 3,7,11,15-TETRAMETHYL-2,4,6,10,14-HEXADECA PENTAENOIC ACID |
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