PROCESS FOR PREPARING "SEMISYNTHETIC PENICILLINS"

PROCESS FOR PREPARING "SEMISYNTHETIC PENICILLINS"

Bactericidal penicillins (I; R = H, C2-8 alkenyl, substituted C2-8 alkenyl, C2-8 alkenyl, substituted C2-8 alkyl, phenyl) having improved stability in aq. soln. and their nontoxic salt, were prepd. by reaction of II and III. Thus, 2.5 ml of 20%(W/W) NaOH in 1.2 ml propionaldehyde and 6.5 g amoxycill...

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Bibliographische Detailangaben
Hauptverfasser: NEWMARK H, EMODI A, SCIALPI L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Bactericidal penicillins (I; R = H, C2-8 alkenyl, substituted C2-8 alkenyl, C2-8 alkenyl, substituted C2-8 alkyl, phenyl) having improved stability in aq. soln. and their nontoxic salt, were prepd. by reaction of II and III. Thus, 2.5 ml of 20%(W/W) NaOH in 1.2 ml propionaldehyde and 6.5 g amoxycillin trihydrate in 100 ml H20 were reacted and filtered with filter paper(0.45 mμ pore). The reactant was cooled to -60 C and dried to give I(R = Et) (C19H29N3O5SNa1.5H2O; M.W. 454.47; m.p. 220 C).