Sustained release transdermal delivery system containing high dose donepezil

Sustained release transdermal delivery system containing high dose donepezil

본 발명은 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것으로, 보다 상세하게는 도네페질 함유 경구투여 제제와 비교하여 동등한 약물동태를 나타내는 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것이다. 본 발명에 따른 도네페질 경피흡수제제는 패치의 면적, 도네페질의 함량 및 피부투과속도를 조절함으로써 경구 투여제보다 낮은 빈도로 처방하면서 경구 투여제와 동등한 수준의 안정적인 도네페질 혈중 농도를 달성할 수 있어, 환자의 복약 순응도를 높이고 경구투여에 따른 부작용을 감소시킬 수 있다. The present inve...

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Hauptverfasser: KIM SEONGSU, HONG DONGHYUN, CHANG KWAN YOUNG, CHOI YOUNG KWEON
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Sprache:eng ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator KIM SEONGSU
HONG DONGHYUN
CHANG KWAN YOUNG
CHOI YOUNG KWEON
description 본 발명은 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것으로, 보다 상세하게는 도네페질 함유 경구투여 제제와 비교하여 동등한 약물동태를 나타내는 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것이다. 본 발명에 따른 도네페질 경피흡수제제는 패치의 면적, 도네페질의 함량 및 피부투과속도를 조절함으로써 경구 투여제보다 낮은 빈도로 처방하면서 경구 투여제와 동등한 수준의 안정적인 도네페질 혈중 농도를 달성할 수 있어, 환자의 복약 순응도를 높이고 경구투여에 따른 부작용을 감소시킬 수 있다. The present invention relates to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation and, more specifically, to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation which exhibits equivalent pharmacokinetics when compared to a donepezil-containing orally administered formulation, and which can increase patient medication compliance and decrease side effects.
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fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20240146479A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20240146479A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20240146479A3</originalsourceid><addsrcrecordid>eNqNy7EKwjAURuEsDqK-wwVnodagOIoogk7qXi7N3zaQJiE3CvXpVfABnM7ynbG63B6S2XoYSnBgAeXEXgxSz44MnH0iDSSDZPRUB__V1rfU2bYjEz6DCR4RL-umatSwE8x-naj58XDfnxaIoYJEruGRq_O1LEpdLPVab7a71X_qDebgN5M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Sustained release transdermal delivery system containing high dose donepezil</title><source>esp@cenet</source><creator>KIM SEONGSU ; HONG DONGHYUN ; CHANG KWAN YOUNG ; CHOI YOUNG KWEON</creator><creatorcontrib>KIM SEONGSU ; HONG DONGHYUN ; CHANG KWAN YOUNG ; CHOI YOUNG KWEON</creatorcontrib><description>본 발명은 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것으로, 보다 상세하게는 도네페질 함유 경구투여 제제와 비교하여 동등한 약물동태를 나타내는 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것이다. 본 발명에 따른 도네페질 경피흡수제제는 패치의 면적, 도네페질의 함량 및 피부투과속도를 조절함으로써 경구 투여제보다 낮은 빈도로 처방하면서 경구 투여제와 동등한 수준의 안정적인 도네페질 혈중 농도를 달성할 수 있어, 환자의 복약 순응도를 높이고 경구투여에 따른 부작용을 감소시킬 수 있다. The present invention relates to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation and, more specifically, to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation which exhibits equivalent pharmacokinetics when compared to a donepezil-containing orally administered formulation, and which can increase patient medication compliance and decrease side effects.</description><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20241008&amp;DB=EPODOC&amp;CC=KR&amp;NR=20240146479A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20241008&amp;DB=EPODOC&amp;CC=KR&amp;NR=20240146479A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM SEONGSU</creatorcontrib><creatorcontrib>HONG DONGHYUN</creatorcontrib><creatorcontrib>CHANG KWAN YOUNG</creatorcontrib><creatorcontrib>CHOI YOUNG KWEON</creatorcontrib><title>Sustained release transdermal delivery system containing high dose donepezil</title><description>본 발명은 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것으로, 보다 상세하게는 도네페질 함유 경구투여 제제와 비교하여 동등한 약물동태를 나타내는 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것이다. 본 발명에 따른 도네페질 경피흡수제제는 패치의 면적, 도네페질의 함량 및 피부투과속도를 조절함으로써 경구 투여제보다 낮은 빈도로 처방하면서 경구 투여제와 동등한 수준의 안정적인 도네페질 혈중 농도를 달성할 수 있어, 환자의 복약 순응도를 높이고 경구투여에 따른 부작용을 감소시킬 수 있다. The present invention relates to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation and, more specifically, to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation which exhibits equivalent pharmacokinetics when compared to a donepezil-containing orally administered formulation, and which can increase patient medication compliance and decrease side effects.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAURuEsDqK-wwVnodagOIoogk7qXi7N3zaQJiE3CvXpVfABnM7ynbG63B6S2XoYSnBgAeXEXgxSz44MnH0iDSSDZPRUB__V1rfU2bYjEz6DCR4RL-umatSwE8x-naj58XDfnxaIoYJEruGRq_O1LEpdLPVab7a71X_qDebgN5M</recordid><startdate>20241008</startdate><enddate>20241008</enddate><creator>KIM SEONGSU</creator><creator>HONG DONGHYUN</creator><creator>CHANG KWAN YOUNG</creator><creator>CHOI YOUNG KWEON</creator><scope>EVB</scope></search><sort><creationdate>20241008</creationdate><title>Sustained release transdermal delivery system containing high dose donepezil</title><author>KIM SEONGSU ; HONG DONGHYUN ; CHANG KWAN YOUNG ; CHOI YOUNG KWEON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240146479A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2024</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM SEONGSU</creatorcontrib><creatorcontrib>HONG DONGHYUN</creatorcontrib><creatorcontrib>CHANG KWAN YOUNG</creatorcontrib><creatorcontrib>CHOI YOUNG KWEON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM SEONGSU</au><au>HONG DONGHYUN</au><au>CHANG KWAN YOUNG</au><au>CHOI YOUNG KWEON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Sustained release transdermal delivery system containing high dose donepezil</title><date>2024-10-08</date><risdate>2024</risdate><abstract>본 발명은 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것으로, 보다 상세하게는 도네페질 함유 경구투여 제제와 비교하여 동등한 약물동태를 나타내는 고용량 도네페질 약물탑재 지속방출 경피흡수제제에 관한 것이다. 본 발명에 따른 도네페질 경피흡수제제는 패치의 면적, 도네페질의 함량 및 피부투과속도를 조절함으로써 경구 투여제보다 낮은 빈도로 처방하면서 경구 투여제와 동등한 수준의 안정적인 도네페질 혈중 농도를 달성할 수 있어, 환자의 복약 순응도를 높이고 경구투여에 따른 부작용을 감소시킬 수 있다. The present invention relates to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation and, more specifically, to a high-dose donepezil drug-loaded sustained-release transdermal delivery formulation which exhibits equivalent pharmacokinetics when compared to a donepezil-containing orally administered formulation, and which can increase patient medication compliance and decrease side effects.</abstract><oa>free_for_read</oa></addata></record>
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Sustained release transdermal delivery system containing high dose donepezil
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