항-ASGR1 폴리펩타이드 및 면역 내성을 위한 사용 방법

본 명세서에는 아시알로당단백질 수용체 1(ASGR1)에 결합하는 결합 폴리펩타이드 및 이를 사용하여 관심 항원에 대한 면역 내성을 유도하는 방법, 예를 들어 관심 항원에 대한 원치 않는 면역 반응과 관련된 질병 또는 장애, 예컨대 자가면역 질환을 치료, 개선, 억제 또는 예방하는 방법이 개시된다. Disclosed herein are binding polypeptides that bind to asialoglycoprotein receptor 1 (ASGR1), and methods of use thereof for inducing...

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Hauptverfasser: WASSAF DINA SAMI, PAULI NOEL THOMAS, GOLDSTEIN REBECCA ILENE, KONTOS STEPHAN, CONLEY GREGORY PAUL, SILVERMAN JULIE MICHELLE, NIELSON NELS PETER II
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creator WASSAF DINA SAMI
PAULI NOEL THOMAS
GOLDSTEIN REBECCA ILENE
KONTOS STEPHAN
CONLEY GREGORY PAUL
SILVERMAN JULIE MICHELLE
NIELSON NELS PETER II
description 본 명세서에는 아시알로당단백질 수용체 1(ASGR1)에 결합하는 결합 폴리펩타이드 및 이를 사용하여 관심 항원에 대한 면역 내성을 유도하는 방법, 예를 들어 관심 항원에 대한 원치 않는 면역 반응과 관련된 질병 또는 장애, 예컨대 자가면역 질환을 치료, 개선, 억제 또는 예방하는 방법이 개시된다. Disclosed herein are binding polypeptides that bind to asialoglycoprotein receptor 1 (ASGR1), and methods of use thereof for inducing immune tolerance against antigens of interest, for example, for treating, ameliorating, inhibiting, or preventing disease or disorders associated with unwanted immune response against the antigens of interest, such as autoimmune diseases.
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Disclosed herein are binding polypeptides that bind to asialoglycoprotein receptor 1 (ASGR1), and methods of use thereof for inducing immune tolerance against antigens of interest, for example, for treating, ameliorating, inhibiting, or preventing disease or disorders associated with unwanted immune response against the antigens of interest, such as autoimmune diseases.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 항-ASGR1 폴리펩타이드 및 면역 내성을 위한 사용 방법
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