보체 인자 I-관련 조성물 및 방법
야생형 CFI에 대해 적어도 하나의 개선된 특징을 나타내는 보체 인자 I(CFI) 변이체 및 CFI 포함 융합 작제물이 본원에 제공된다. 본 개시내용의 CFI 변이체 및 융합 작제물은 조정 가능한 특이성 및 활성을 나타낼 수 있다. 본원에 제공된 CFI 변이체 및 융합 작제물은 보체계의 조절장애 또는 CFI 결핍과 연관된 질환 또는 병태를 치료하는 데 유용할 수 있다. Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs...
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creator | MCGUIRE JAMES N PELOT KYLE A BLOUSE GRANT E SCHAR CHRISTINE RENE IYER SHYAM RAJAN JENSEN JAN KRISTIAN OLDENBURG EMIL JENDROSZEK AGNIESZKA |
description | 야생형 CFI에 대해 적어도 하나의 개선된 특징을 나타내는 보체 인자 I(CFI) 변이체 및 CFI 포함 융합 작제물이 본원에 제공된다. 본 개시내용의 CFI 변이체 및 융합 작제물은 조정 가능한 특이성 및 활성을 나타낼 수 있다. 본원에 제공된 CFI 변이체 및 융합 작제물은 보체계의 조절장애 또는 CFI 결핍과 연관된 질환 또는 병태를 치료하는 데 유용할 수 있다.
Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI. |
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Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.</description><language>kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240731&DB=EPODOC&CC=KR&NR=20240117138A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240731&DB=EPODOC&CC=KR&NR=20240117138A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MCGUIRE JAMES N</creatorcontrib><creatorcontrib>PELOT KYLE A</creatorcontrib><creatorcontrib>BLOUSE GRANT E</creatorcontrib><creatorcontrib>SCHAR CHRISTINE RENE</creatorcontrib><creatorcontrib>IYER SHYAM RAJAN</creatorcontrib><creatorcontrib>JENSEN JAN KRISTIAN</creatorcontrib><creatorcontrib>OLDENBURG EMIL</creatorcontrib><creatorcontrib>JENDROSZEK AGNIESZKA</creatorcontrib><title>보체 인자 I-관련 조성물 및 방법</title><description>야생형 CFI에 대해 적어도 하나의 개선된 특징을 나타내는 보체 인자 I(CFI) 변이체 및 CFI 포함 융합 작제물이 본원에 제공된다. 본 개시내용의 CFI 변이체 및 융합 작제물은 조정 가능한 특이성 및 활성을 나타낼 수 있다. 본원에 제공된 CFI 변이체 및 융합 작제물은 보체계의 조절장애 또는 CFI 결핍과 연관된 질환 또는 병태를 치료하는 데 유용할 수 있다.
Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB-vXnLm01bFN7M3fFm3gQFT91XWxpeL1ih8GbhhjctG1-v2aPwekM_EK98vWkqDwNrWmJOcSovlOZmUHZzDXH20E0tyI9PLS5ITE7NSy2J9w4yMjAyMTA0NDc0tnA0Jk4VABoINZ8</recordid><startdate>20240731</startdate><enddate>20240731</enddate><creator>MCGUIRE JAMES N</creator><creator>PELOT KYLE A</creator><creator>BLOUSE GRANT E</creator><creator>SCHAR CHRISTINE RENE</creator><creator>IYER SHYAM RAJAN</creator><creator>JENSEN JAN KRISTIAN</creator><creator>OLDENBURG EMIL</creator><creator>JENDROSZEK AGNIESZKA</creator><scope>EVB</scope></search><sort><creationdate>20240731</creationdate><title>보체 인자 I-관련 조성물 및 방법</title><author>MCGUIRE JAMES N ; PELOT KYLE A ; BLOUSE GRANT E ; SCHAR CHRISTINE RENE ; IYER SHYAM RAJAN ; JENSEN JAN KRISTIAN ; OLDENBURG EMIL ; JENDROSZEK AGNIESZKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20240117138A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>kor</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MCGUIRE JAMES N</creatorcontrib><creatorcontrib>PELOT KYLE A</creatorcontrib><creatorcontrib>BLOUSE GRANT E</creatorcontrib><creatorcontrib>SCHAR CHRISTINE RENE</creatorcontrib><creatorcontrib>IYER SHYAM RAJAN</creatorcontrib><creatorcontrib>JENSEN JAN KRISTIAN</creatorcontrib><creatorcontrib>OLDENBURG EMIL</creatorcontrib><creatorcontrib>JENDROSZEK AGNIESZKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MCGUIRE JAMES N</au><au>PELOT KYLE A</au><au>BLOUSE GRANT E</au><au>SCHAR CHRISTINE RENE</au><au>IYER SHYAM RAJAN</au><au>JENSEN JAN KRISTIAN</au><au>OLDENBURG EMIL</au><au>JENDROSZEK AGNIESZKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>보체 인자 I-관련 조성물 및 방법</title><date>2024-07-31</date><risdate>2024</risdate><abstract>야생형 CFI에 대해 적어도 하나의 개선된 특징을 나타내는 보체 인자 I(CFI) 변이체 및 CFI 포함 융합 작제물이 본원에 제공된다. 본 개시내용의 CFI 변이체 및 융합 작제물은 조정 가능한 특이성 및 활성을 나타낼 수 있다. 본원에 제공된 CFI 변이체 및 융합 작제물은 보체계의 조절장애 또는 CFI 결핍과 연관된 질환 또는 병태를 치료하는 데 유용할 수 있다.
Provided herein are Complement Factor I (CFI) variants and CFI containing fusion constructs that exhibit at least one improved characteristic relative to a wild type CFI. The CFI variants and fusion constructs of the disclosure can exhibit tunable specificity and activity. The CFI variants and fusion constructs provided herein may be useful for treating a disease or condition associated with dysregulation of the complement system or a deficiency of CFI.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
title | 보체 인자 I-관련 조성물 및 방법 |
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