STING 작용제로서 융합된 헤테로아릴 히드록사메이트

본 발명은 화학식 I로 나타낸 신규한 치환된 이종환식 화합물, 또는 이들의 약제학적으로 허용가능한 염, 용매화물, 다형체, 에스테르, 호변이성질체 또는 전구약물, 및 이러한 화합물을 포함하는 조성물을 제공한다. 제공된 화합물은 인터페론 유전자의 자극제(STING)의작용제로서 사용될 수있으며, 암 및 특정한 감염성 질환의 치료에 유용하다. [화학식 I] JPEGpct00100.jpg6352 The invention provides novel substituted heterocyclic compounds represented by th...

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Hauptverfasser: JEON SUNHWA, JEON SEEUN, LEE JINWOO, YANG INHO, KIM SUNJOO, LEE JUNGWOO, YOON CHEOLHWAN, HAN CHEOLKYU, SHIN YOUNGDO, KANG BYUNGNAM, SEO JEONGBEOB, KANG HONGJUN
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creator JEON SUNHWA
JEON SEEUN
LEE JINWOO
YANG INHO
KIM SUNJOO
LEE JUNGWOO
YOON CHEOLHWAN
HAN CHEOLKYU
SHIN YOUNGDO
KANG BYUNGNAM
SEO JEONGBEOB
KANG HONGJUN
description 본 발명은 화학식 I로 나타낸 신규한 치환된 이종환식 화합물, 또는 이들의 약제학적으로 허용가능한 염, 용매화물, 다형체, 에스테르, 호변이성질체 또는 전구약물, 및 이러한 화합물을 포함하는 조성물을 제공한다. 제공된 화합물은 인터페론 유전자의 자극제(STING)의작용제로서 사용될 수있으며, 암 및 특정한 감염성 질환의 치료에 유용하다. [화학식 I] JPEGpct00100.jpg6352 The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator of Interferon Genes (STING) and are useful in the treatment of cancers and certain infectious diseases.
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[화학식 I] JPEGpct00100.jpg6352 The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. 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[화학식 I] JPEGpct00100.jpg6352 The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. 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[화학식 I] JPEGpct00100.jpg6352 The invention provides novel substituted heterocyclic compounds represented by the Formulas I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as agonists of Stimulator of Interferon Genes (STING) and are useful in the treatment of cancers and certain infectious diseases.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title STING 작용제로서 융합된 헤테로아릴 히드록사메이트
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